Methotrexate Accumulation In Patient Guts: Target Intestinal Mucosa Variation By Disease State Overview This study investigates the accumulation of intracellular methotrexate polyglutamates (MTX-PGs) in different cell types to identify a more accurate biomarker for methotrexate (MTX) therapy in Crohn’s disease (CD) patients. MTX-PG3 concentrations in red blood cells (RBCs) are known to
Author: Nancy Ogbonna
Valoctocogene Roxaparvovec Gene Therapy Success Detailed For Hemophilia A Patients
Valoctocogene Roxaparvovec Gene Therapy Success Detailed For Hemophilia A Patients Overview Valoctocogene roxaparvovec is a gene therapy utilizing an adeno-associated virus serotype 5 (AAV5) vector, approved for treating severe hemophilia A (HA). The purpose of this summary is to present the safety and efficacy outcomes observed seven years post-dosing in a phase
Efgartigimod Provides Genuine Benefit For Myasthenia Gravis Disease
Efgartigimod Provides Genuine Benefit For Myasthenia Gravis Disease Overview Efgartigimod, a neonatal Fc receptor inhibitor, has recently received approval for the treatment of myasthenia gravis (MG). This retrospective cohort study systematically evaluated the short- and long-term efficacy of efgartigimod in patients with refractory MG. Sixteen patients with autoimmune acetylcholine receptor MG, who
Bone Mineral Density In Menopause Patients: A Focus On Inflammation
Bone Mineral Density In Menopause Patients: A Focus On Inflammation Overview This study aimed to explore the relationship between changes in bone mineral density (BMD) and circulating inflammatory markers in postmenopausal women. Conducted retrospectively, the study focused on women admitted to the orthopedic department at Suzhou Benq Medical Center between June 2022
Colitis Risk Increase In Inflammatory Eye Disease Patients
Colitis Risk Increase In Inflammatory Eye Disease Patients Overview Microscopic colitis (MC) is an inflammatory condition affecting the colon, but its association with inflammatory eye diseases remains unclear. This study aimed to determine if inflammatory eye diseases, specifically iridocyclitis and episcleritis, are risk factors for developing MC. Using the ESPRESSO database, which includes
Meibomian Gland Damaging By Glaucoma Treatments
Meibomian Gland Damaging By Glaucoma Treatments Overview Glaucoma is one of the leading causes of blindness worldwide, with a strong link to elevated intraocular pressure (IOP). Effective management of glaucoma primarily involves lowering IOP, usually through the use of topical eye drops. The health of the meibomian glands is crucial for maintaining
Sjögren’s Disease Leads To Mental Health Meltdown
Sjögren’s Disease Leads To Mental Health Meltdown Overview Primary Sjögren’s syndrome (pSS) is a well-known autoimmune disorder characterized by inflammation of the glands, leading to symptoms such as dry eyes and mouth. While traditionally associated with peripheral glandular issues, Sjögren’s syndrome also impacts the central nervous system (CNS), manifesting in various neuropsychiatric
Grape Syrup Improved Hemoglobin In Anemic Women
Grape Syrup Improved Hemoglobin In Anemic Women Overview Iron deficiency is the most common nutritional disorder worldwide, with anemia particularly affecting women of childbearing age. Although current treatments, such as iron supplements, are effective, they often come with side effects. This study investigates the potential of grape syrup (GS), a functional food
Dermatitis: A Comprehensive Prevalence And Quality Of Life Study
Dermatitis: A Comprehensive Prevalence And Quality Of Life Study Overview The survey involved individuals aged 16 and older from 20 countries. Quota sampling was employed to reflect the population distribution by age, sex, environment, and income. Participants completed a structured questionnaire and were identified as having seborrheic scalp dermatitis (SSD) if they
Morphea In Inflammation: Highest And Lowest Dermal Readings
Morphea In Inflammation: Highest And Lowest Dermal Readings Overview To date, there are no standardized outcome measures for monitoring morphea, and establishing consensus on specific monitoring criteria has been challenging. Few studies have evaluated the criterion validity of skin ultrasound in morphea. This study aims to investigate ultrasound findings in morphea lesions. This
