Busulfan Exposure And Malignancy Risk

Busulfan Exposure And Malignancy Risk Overview The occurrence of secondary malignancies linked to busulfan exposure is deemed low but remains insufficiently characterized. Given the rising use of this alkylating agent in pre-gene therapy conditioning for nonmalignant hematologic disorders, a more precise understanding of busulfan's potential contribution to subsequent malignancy risk is essential.

Thromboembolism Risk In Pregnant Oncology Patients

Thromboembolism Risk In Pregnant Oncology Patients Overview This systematic review and meta-analysis investigated the incidence of venous thromboembolism (VTE) in pregnant individuals with active malignancy compared to those without malignancy. The study, based on seven cohort studies encompassing 5,928 individuals with both active malignancy and pregnancy, yielded the following key findings:  

Testicular Cancer And Psychological Distress

Testicular Cancer And Psychological Distress In 2020, testicular cancer (TC) affected 74,458 men, representing 0.4% of global cancer cases. Predominant among young men of European descent, TC's primary treatment involves orchiectomy, boasting a substantial 95% 5-year survival rate.  However, the aftermath includes enduring psychological distress, with 20% of men grappling with emotional

Spontaneous Bladder Rupture In Bladder Cancer Patients

Spontaneous Bladder Rupture In Bladder Cancer Patients Spontaneous rupture of the urinary bladder is an uncommon yet severe condition in which the bladder wall tears, occurring without any associated trauma or instrumentation. This means that the bladder, without any external force or medical procedure, experiences a tear or perforation. The rarity

Prostate Cancer Detection Using Urine Glycoproteins

Prostate Cancer Detection Using Urine Glycoproteins Overview In a recent study, researchers investigated the potential of using pre-digital rectal examination (DRE) urine specimens to detect aggressive prostate cancer (AG-PCa) by comparing glycoproteins found in pre- and post-DRE urine samples. The study involved 154 pre-DRE urine specimens from individuals with no cancer at

lung cancer patients and pulmonary embolism risk factors

lung cancer patients and pulmonary embolism risk factors Overview Pulmonary embolism (PE) is a grave complication observed in individuals afflicted with lung cancer. This investigation aimed to ascertain the risk factors and evaluate the clinical attributes of advanced lung cancer patients who develop PE.   In this research, a retrospective assessment was conducted on

Spitz Lesions: Clinical Outcomes

Spitz Lesions: Clinical Outcomes Overview The management of Spitz-type lesions in clinical practice has been a subject of debate due to the limited information available on their long-term clinical outcomes. Some medical centers opt for a conservative and observational approach, while others recommend further surgery and extended follow-up. The objective of this

Cabozantinib Therapy In Hepatocellular Carcinoma

Cabozantinib Therapy In Hepatocellular Carcinoma Hepatocellular carcinoma (HCC) is a predominant form of liver cancer, accounting for approximately 90% of cases. Unfortunately, it carries a grim prognosis, with a median survival rate ranging from 6 to 18 months. Historically, sorafenib had been the established first-line therapy for HCC. However, in recent

Encapsulated Papillary Carcinoma Membrane Characteristics

Encapsulated Papillary Carcinoma Membrane Characteristics Overview This study focused on encapsulated papillary carcinoma (EPC), a type of breast carcinoma characterized by a thick fibrous capsule-like structure surrounding the tumor, often interpreted as a thickened basement membrane (BM). The primary objective was to investigate the geometric properties of the EPC capsule and determine

Busulfan Exposure And Malignancy Risk