Ganaxolone Treatment For Refractory Epilepsy Overview In a meta-analysis conducted to evaluate the use of ganaxolone for refractory epilepsy, researchers collected data from four randomized controlled trials involving a total of 659 patients. The analysis revealed that ganaxolone significantly improved the reduction in mean seizure frequency by ≥50% when compared to a
Neurology
Bipolar Disorder And The Impact Of Insulin Sensitivity
Bipolar Disorder And The Impact Of Insulin Sensitivity Overview This study investigated the impact of insulin resistance (IR) and insulin sensitivity on various brain parameters in individuals with bipolar disorder (BD). Bipolar disorder is associated with structural and functional brain changes, and BD patients have an increased risk of developing insulin resistance,
Postoperative Delirium In The NICU: Hormonal Risk Factors
Postoperative Delirium In The NICU: Hormonal Risk Factors In neurosurgery, pituitary adenoma ranks as the second most common brain tumor. Recent advances in endoscope-assisted transsphenoidal surgery have revolutionized tumor resection, reducing complications. However, postoperative complications, particularly endocrine-related issues, remain critical in neurosurgical intensive care units (NICUs). Notably, postoperative delirium, intricately linked
Hormone Disturbances in Migraine Disorder: A Meta-Analysis
Hormone Disturbances in Migraine Disorder: A Meta-Analysis Overview Migraine, a prevalent cause of disability among young adults, displays a higher incidence in females and is often accompanied by stress-related disorders, hinting at a potential link with sex and stress-related hormonal mechanisms centered around the hypothalamus. Additionally, interactions with autonomic nervous system activity
IGF-1 Levels In Pediatric Low-Grade Gliomas
IGF-1 Levels In Pediatric Low-Grade Gliomas Overview This study investigated elevated insulin-like growth factor 1 (IGF-1) levels in children with low-grade glioma (LGG). Elevated IGF-1 levels in LGG are not well understood. The research aimed to determine the prevalence, connections with growth, body mass index (BMI), pituitary function, and tumor behavior in
Visual Field Defects in Patients with Pituitary Tumors
Visual Field Defects in Patients with Pituitary Tumors Overview Automated perimetry is a standardized technique for assessing the visual field, commonly using the Humphrey Field Analyser (HFA) with the 24-2 or 30-2 test patterns. This study aimed to determine if the 24-2 test pattern could yield similar outcomes as the 30-2 pattern
Diabetic Peripheral Neuropathy Diagnosis Using Nerve Ultrasonography
Diabetic Peripheral Neuropathy Diagnosis Using Nerve Ultrasonography Overview The conventional diagnostic modality for diabetic peripheral neuropathy is via the use of nerve conduction studies (NCS), however, this investigation does not evaluate or demonstrate the structure of the nerve. This research was aimed at investigating the use of peripheral nerve ultrasonography as a
Merkel Cell Carcinoma: A Case Of Metastasis to the Tonsils
Merkel Cell Carcinoma: A Case Of Metastasis to the Tonsils Overview Tonsillar metastases of Merkel cell carcinoma (MCC) are very rare. There are as few as five documented and published cases. In this report, we present a case of palatine tonsillar Merkel cell carcinoma metastases in a patient who did not show
Maternal Migraines And Associated Pediatric Cancers
Maternal Migraines And Associated Pediatric Cancers Overview Maternal migraines are seen to be associated with unfavorable birth outcomes such as congenital malformations in babies, preterm births and infant low birth weight. It has been hypothesized that these unfavorable or adverse birth outcomes may be due to the intake of certain medications during
Pediatric Neuroblastoma Diagnosis Using Urinary Catecholamine Metabolites
Pediatric Neuroblastoma Diagnosis Using Urinary Catecholamine Metabolites Overview Urinary catecholamine metabolite analysis is a valuable tool in the diagnosis of neuroblastoma. There is currently no agreement with regard to the method of sampling and variable catecholamine metabolite combinations being utilized. In this study, we assessed the reliability of spot urine samples in
