Off-label Medication Use In Oncology Cancer Research and Medicinal Drugs Cancer research and innovation are highly active, resulting in the introduction of new medications into the therapeutic arsenal. However, incorporating these new drugs into clinical practice is a challenging and time-consuming process due to regulatory requirements. Before a drug can be marketed and
Internal Medicine
Chronic Hyponatremia in Acute Heart Failure
Chronic Hyponatremia in Acute Heart Failure Overview This study aimed to comprehensively assess hyponatremia in patients with acute heart failure (AHF), focusing on its prevalence, associations, hospital course, and post-discharge outcomes. The research analyzed a cohort of 8,298 AHF patients from the European Society of Cardiology Heart Failure Long-Term Registry, regardless of
Massage Therapy For Oncology Patient Pain
Massage Therapy For Oncology Patient Pain Overview This study aimed to investigate the impact of massage therapy (MT) as a nonpharmacologic approach for addressing various symptoms experienced by children, adolescents, and young adults with hematologic and/or oncologic conditions. The researchers focused on two patient groups: those with sickle cell disease (SCD) and
Eyelid Rhabdomyosarcoma Survival In Children’s Oncology
Eyelid Rhabdomyosarcoma Survival In Children's Oncology Overview Survival outcomes in Orbital Rhabdomyosarcoma (ORMS) typically show excellent results, especially in low-risk cases (stage 1, group I-III, embryonal RMS). However, long-term follow-up data on low-risk ORMS and less common subgroups treated in recent Children's Oncology Group (COG) trials were previously unreported. To fill this
Injured Athletes: A Meta-Analysis Comparing Topical And Oral Analgesic Efficacy
Injured Athletes: A Meta-Analysis Comparing Topical And Oral Analgesic Efficacy Overview Injured athletes often resort to analgesic medication for pain relief, employing both non-prescription topical and oral medications without comprehensive guidance. However, the efficacy of such pain medications in injured athletes, as compared to a placebo, has not been extensively studied. To
Sarcopenia And Chronic Kidney Disease
Sarcopenia And Chronic Kidney Disease Overview Sarcopenia and frailty are common conditions among people with chronic kidney disease (CKD), which may further enhance their risk of developing adverse health complications. Only a few studies have demonstrated the association between sarcopenia, frailty and chronic kidney disease in patients who are not on dialysis.
Childhood Obesity: Targeted Dietary Interventions
Childhood Obesity: Targeted Dietary Interventions Childhood obesity is a global concern, and dietary interventions have shown varying effectiveness in reducing BMI in children and adolescents. However, there is little guidance on targeted dietary approaches and energy reduction, leading to inconsistent recommendations. This excellent systematic review aimed to assess the effectiveness of
Supragastric Belching And Acid Reflux Severity
Supragastric Belching And Acid Reflux Severity SGB, known as supragastric belching, is a behavioral disorder where individuals rapidly inhale and expel air. It is commonly observed in those experiencing symptoms resembling acid reflux, as well as in individuals with excessive belching. Studies in the past have indicated a higher prevalence of
Diabetic Peripheral Neuropathy Diagnosis Using Nerve Ultrasonography
Diabetic Peripheral Neuropathy Diagnosis Using Nerve Ultrasonography Overview The conventional diagnostic modality for diabetic peripheral neuropathy is via the use of nerve conduction studies (NCS), however, this investigation does not evaluate or demonstrate the structure of the nerve. This research was aimed at investigating the use of peripheral nerve ultrasonography as a
IBD: A Link To Cancer And Infection
IBD: A Link To Cancer And Infection Individuals diagnosed with inflammatory bowel disease (IBD) face higher susceptibility to malignancy and infection when compared to the general population. The primary objective of this study was to identify and describe risk factors associated with malignancy or serious infection in patients with IBD, with a
