AI Companions & Human Connection: How Artificial Intelligence Is Changing Loneliness Abstract The emergence of artificial intelligence companions represents a fundamental shift in how humans address loneliness and social isolation. This paper examines the growing prevalence of AI companions, their impact on human psychological
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The Dopamine Paradox: Why Pleasure Often Undermines Motivation
The Dopamine Paradox: Why Pleasure Often Undermines Motivation Abstract Purpose: This paper examines the counterintuitive relationship between dopamine-mediated pleasure and human motivation, exploring how immediate gratification can diminish long-term goal pursuit. The analysis focuses on neurobiological mechanisms underlying motivation regulation and their clinical
The Cancer Risk Paradox of Anti-Aging Therapies
The Cancer Risk Paradox of Anti-Aging Therapies Abstract The relationship between anti-aging interventions and cancer risk presents a complex biological paradox that demands careful examination by healthcare practitioners. While many anti-aging therapies aim to promote cellular health and longevity, they may inadvertently create conditions that
Resistant Starch and Short-Chain Fatty Acids: A Comprehensive Review of Physiologic Mechanisms
Resistant Starch and Short-Chain Fatty Acids: A Comprehensive Review of Physiologic Mechanisms and Clinical Relevance Comprehensive Guide Abstract Resistant starch represents a distinct category of dietary carbohydrate that escapes digestion in the small intestine and undergoes fermentation by colonic bacteria. This process generates short-chain fatty
Coronary Artery Calcium–Guided Prevention and Microbiome-Centered Nutrition
Coronary Artery Calcium–Guided Prevention and Microbiome-Centered Nutrition: A Physician-Focused Review Integrating the Clinical Framework of William Davis, MD Quick Summary CAC is most useful when you’re on the fence. In borderline/intermediate-risk patients—or when risk markers conflict—CAC can clarify preventive intensity and improve
Glucagon-Like Peptide-1 Receptor Agonists and Human Fertility
Glucagon-Like Peptide-1 Receptor Agonists and Human Fertility: Mechanisms, Evidence, and Clinical Implications Abstract Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are well established for the treatment of type 2 diabetes mellitus and obesity. Increasingly, reports suggest a possible association between GLP-1 RA use and
Emerging and Approved Therapeutic Peptides: Mechanisms, Clinical Uses
Emerging and Approved Therapeutic Peptides: Mechanisms, Clinical Uses, Safety Profiles, and Regulatory Status Across Health Conditions Abstract Therapeutic peptides represent a rapidly growing class of pharmaceutical agents that bridge the gap between small molecule drugs and large protein therapeutics. This paper examines the
The New Frontier in Longevity Science: Senolytics and Age-Reversal Therapies
The New Frontier in Longevity Science: Senolytics and Age-Reversal Therapies Introduction Approximately 80% of adults over age 65 worldwide develop at least one chronic condition, from arthritis to dementia. Recent longevity research has identified cellular senescence as a fundamental driver of age-related decline. These
BPH Treatment Guidelines 2025: Expert-Validated Algorithm for Patient Care
BPH Treatment Guidelines 2025: Expert-Validated Algorithm for Patient Care Introduction Benign prostatic hyperplasia (BPH) treatment guidelines continue to evolve as the condition affects an overwhelming majority of aging men, with prevalence rates reaching 60% by age 60 and escalating to 80% by age
Why Medicine Feels Broken- And What Doctors Are Doing to Reclaim Their Lives
Why Medicine Feels Broken — And What Doctors Are Doing to Reclaim Their Lives Abstract The medical profession faces an unprecedented crisis marked by widespread physician burnout, administrative burden, and declining job satisfaction. This analysis examines the systemic factors contributing to the perception
