Tau Accumulation And White Matter Changes Linked To Hypertension Overview This study explored how amyloid buildup and hypertension interact to affect tau accumulation and atrophy in the entorhinal cortex (EC), while also investigating cerebral blood flow (CBF) as a potential shared mechanism. The researchers analyzed data from two cohorts of older adults
Tag: Alzheimer’s disease
Alzheimer’s Disease Revealed By Reliable Digital Memory Assessments
Alzheimer's Disease Revealed By Reliable Digital Memory Assessments Alzheimer's disease (AD) research has advanced in detecting pathological changes through biomarkers, but cognitive measures lag in capturing early, subtle impairments. Traditional assessments designed for overt deficits are now outpaced by discoveries in episodic memory networks within the medial temporal lobe, which are
Dementia Risk Increase In Diabetic Patients With Poor Glycemic Control
Dementia Risk Increase In Diabetic Patients With Poor Glycemic Control Overview This study investigated the association between glycemic variability and dementia risk among 171,964 individuals with type 2 diabetes. Despite optimal glycosylated hemoglobin A1c (HbA1c) levels, variability in HbA1c over the long term was found to increase the hazard of dementia. The
Nanosized Traditional Chinese Medicine Technology To Overcome The Blood-Brain Barrier
Nanosized Traditional Chinese Medicine Technology To Overcome The Blood-Brain Barrier Overview This review explores the intersection of traditional Chinese medicine (TCM) and nanotechnology, known as nano-TCM, as a promising avenue for overcoming the challenges posed by the blood-brain barrier (BBB) in treating central nervous system (CNS) diseases. While TCM has demonstrated efficacy
Dementia Risk Assessed By Brain Artery Diameter
Dementia Risk Assessed By Brain Artery Diameter Overview In this study, the association between brain artery diameters and the risk of dementia and stroke was investigated across three distinct population-based studies utilizing conventional T2-weighted brain magnetic resonance imaging (MRI) images. A total of 8,420 adults aged over 40 years from these longitudinal
Alzheimer’s Patients and Low Tau Burden Outcomes
Alzheimer's Patients and Low Tau Burden Outcomes Overview The study focuses on individuals within the Alzheimer's Disease (AD) pathway exhibiting abnormal amyloid-beta (Aβ) and tau deposition. Specifically, it investigates a subgroup characterized by low tau levels (A+T−) and compares them to their counterparts with higher tau levels (A+T+). The research involves 397 individuals
Multimorbidity In Patients With Cognitive Impairment And Dementia
Multimorbidity In Patients With Cognitive Impairment And Dementia Overview The study aimed to investigate the burden and clusters of multimorbidity in relation to mild cognitive impairment (MCI), dementia, and Alzheimer's disease (AD)-related plasma biomarkers among older adults. A population-based sample of 5432 participants aged 60 years and above was included, with a
Anticholinergic Medications And Cognitive Outcomes In Autistic Adults
Anticholinergic Medications And Cognitive Outcomes In Autistic Adults Overview This study investigates the impact of anticholinergic (AC) medications on cognitive outcomes in autistic adults, an area that has not been extensively researched. AC medications, known for their potential to cause cognitive impairment, are commonly used for various medical and psychiatric conditions. In
Antidiabetic Medications And Dementia Risk
Antidiabetic Medications And Dementia Risk Overview This umbrella review and meta-analysis aimed to assess the impact of diabetes on dementia risk and investigate the potential mitigating effects of various antidiabetic treatments. The study conducted a systematic review on diabetes and its treatment, along with a meta-analysis specifically focusing on treatment outcomes. A comprehensive
