CRISPR and Gene Editing in Neurodegenerative Diseases Current Applications and Future Therapeutic Potential Abstract Neurodegenerative diseases continue to pose profound challenges to modern medicine, affecting millions of individuals worldwide and contributing significantly to disability, mortality, and healthcare expenditure. Disorders such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease,
Tag: Alzheimer’s disease
Why Tau Antibody Trials Failed in Alzheimer’s: New Evidence Reveals Critical Gaps
Why Tau Antibody Trials Failed in Alzheimer’s New Evidence Reveals Critical Gaps Introduction Tau directed antibody therapies represent one of the most scientifically compelling yet clinically challenging areas in the treatment of Alzheimer’s disease. Alzheimer’s disease is a progressive neurodegenerative disorder whose prevalence doubles approximately
Biomarkers for Alzheimer’s Disease: PET to Plasma
Biomarkers for Alzheimer’s Disease: PET to Plasma Abstract Background:The diagnostic landscape of Alzheimer’s disease (AD) has shifted considerably in recent years. Traditional diagnosis relied heavily on clinical assessments supported by neuropsychological testing and structural imaging. These approaches, while valuable, often lacked the sensitivity and specificity needed to
Smart Devices Detect Early Cognitive Decline
Breakthrough: New Alzheimer’s Disease Research Shows Prevention Potential in Clinical Trials
Breakthrough: New Alzheimer’s Disease Research Shows Prevention Potential in Clinical Trials Please like and subscribe if you enjoyed this video :-) Introduction Recent Alzheimer’s disease research reveals a substantial shift from treatment to prevention strategies, offering new hope for millions worldwide. Clinical
The Gut-Brain Connection: How Your Microbiome Affects Neurological Health
Hearing Loss And Functional Decline
Hearing Loss And Functional Decline Overview Hearing loss has been recognized as one of the major modifiable risk factors for cognitive decline and dementia. However, studies exploring this connection have yielded mixed results. This study aimed to assess the long-term relationship between self-reported hearing loss and cognitive/functional abilities in 695 cognitively
Tau Accumulation And White Matter Changes Linked To Hypertension
Tau Accumulation And White Matter Changes Linked To Hypertension Overview This study explored how amyloid buildup and hypertension interact to affect tau accumulation and atrophy in the entorhinal cortex (EC), while also investigating cerebral blood flow (CBF) as a potential shared mechanism. The researchers analyzed data from two cohorts of older adults
Alzheimer’s Disease Revealed By Reliable Digital Memory Assessments
Alzheimer's Disease Revealed By Reliable Digital Memory Assessments Alzheimer's disease (AD) research has advanced in detecting pathological changes through biomarkers, but cognitive measures lag in capturing early, subtle impairments. Traditional assessments designed for overt deficits are now outpaced by discoveries in episodic memory networks within the medial temporal lobe, which are
Dementia Risk Increase In Diabetic Patients With Poor Glycemic Control
Dementia Risk Increase In Diabetic Patients With Poor Glycemic Control Overview This study investigated the association between glycemic variability and dementia risk among 171,964 individuals with type 2 diabetes. Despite optimal glycosylated hemoglobin A1c (HbA1c) levels, variability in HbA1c over the long term was found to increase the hazard of dementia. The
