Prostate Cancer Detection Using Urine Glycoproteins Overview In a recent study, researchers investigated the potential of using pre-digital rectal examination (DRE) urine specimens to detect aggressive prostate cancer (AG-PCa) by comparing glycoproteins found in pre- and post-DRE urine samples. The study involved 154 pre-DRE urine specimens from individuals with no cancer at
Nephrology
Lithium Effects On Renal Function In Geriatric Patients
Lithium Effects On Renal Function In Geriatric Patients Overview The practice of augmenting antidepressant therapy with lithium, known as Lithium Augmentation (LA), is considered a primary treatment option for individuals suffering from Treatment-Resistant Depression (TRD). However, in the case of geriatric patients, this approach is notably underutilized due to concerns surrounding potential
AKI In Alcohol-Related Hepatitis
AKI In Alcohol-Related Hepatitis The prevalence, prediction, and impact of acute kidney injury (AKI) in alcohol-related hepatitis (AH) remain uncertain. AH is the most severe form of alcohol-related liver disease (ARLD) with a 30% mortality rate within 90 days, often aggravated by AKI, either as a primary or secondary cause. Research suggests
PD-1/L1 Inhibitors: Treatment Efficacy In Urothelial Carcinoma
PD-1/L1 Inhibitors: Treatment Efficacy In Urothelial Carcinoma Overview Programmed cell death‐1/ligand 1 (PD-1/PD-L1) inhibitors represent a novel therapeutic approach for advanced urothelial carcinoma, prompting the need for a comparative assessment of their effectiveness and safety in comparison to traditional chemotherapy. To address this, a comprehensive meta-analysis of randomized controlled trials conducted until
Serum Potassium Levels And Mortality Risk in CKD
Serum Potassium Levels And Mortality Risk in CKD Overview The study delved into the impact of serum potassium levels on the health of elderly individuals with chronic kidney disease (CKD) stage 4-5. Hypokalemia and hyperkalemia were recognized as contributors to kidney function decline and sudden cardiac death. However, limited knowledge exists about
Chronic Hyponatremia in Acute Heart Failure
Chronic Hyponatremia in Acute Heart Failure Overview This study aimed to comprehensively assess hyponatremia in patients with acute heart failure (AHF), focusing on its prevalence, associations, hospital course, and post-discharge outcomes. The research analyzed a cohort of 8,298 AHF patients from the European Society of Cardiology Heart Failure Long-Term Registry, regardless of
Sarcopenia And Chronic Kidney Disease
Sarcopenia And Chronic Kidney Disease Overview Sarcopenia and frailty are common conditions among people with chronic kidney disease (CKD), which may further enhance their risk of developing adverse health complications. Only a few studies have demonstrated the association between sarcopenia, frailty and chronic kidney disease in patients who are not on dialysis.
Renal Transplant Risks With Prostate Cancer
Renal Transplant Risks With Prostate Cancer Overview Renal transplant candidates are recommended to undergo a systematic screening for prostate cancer at the time of listing. It is a growing concern that low-risk prostate cancer diagnosis may lead to reduced access to renal transplant services without any significant oncological benefit. The aim of this
Urothelial Carcinoma – Ureteral and Renal Pelvic Tumors
Urothelial Carcinoma - Ureteral and Renal Pelvic Tumors Overview Ureteropelvic and renal pelvic carcinoma have similar origins, however, variations in genetic and clinical parameters makes them two distinct conditions. The single-center data obtained for the molecular subtypes and characteristics of the two muscle-invasive tumors were validated using clinical data from the Surveillance,
Finerenone Therapy In CKD and Type 2 Diabetes
Finerenone Therapy In CKD and Type 2 Diabetes Overview The aim of this study is to assess the effect of finerenone on the duration, progression and complications of type 2 diabetes mellitus. This was achieved by estimating the values of baseline glycated hemoglobin (HbA1c) levels, glycated hemoglobin level variabilities, and the development
