New Frontiers in Sickle Cell Disease: CRISPR-Based Cures

New Frontiers in Sickle Cell Disease: CRISPR-Based Cures Abstract Sickle cell disease (SCD) remains one of the most pressing global health challenges, with an estimated 300,000 infants born annually with the disorder and millions more living with its lifelong complications. The burden of SCD is disproportionately higher in

Venetoclax-based Regimens in AML: The New Standard or a Temporary Fix?

Venetoclax-based Regimens in AML: The New Standard or a Temporary Fix? Abstract Acute myeloid leukemia (AML) remains a challenging hematologic malignancy, particularly among older adults and patients unfit for intensive chemotherapy. Over the past decade, treatment models have shifted with the advent of venetoclax, a selective BCL-2 inhibitor,

Iron Study Interpretation: Why Traditional Tests Miss Functional Deficiency

Iron Study Interpretation: Why Traditional Tests Miss Functional Deficiency Check back later for a possible video summary. Videos are created for most articles.   Introduction Anemia is one of the most common diseases in the world, and iron deficiency anemia is the most

BTK Inhibitors in CLL: New Clinical Evidence Reshapes First-Line Treatment

BTK Inhibitors in CLL: New Clinical Evidence Reshapes First-Line Treatment   Please like and subscribe if you enjoyed this video :-)   Introduction The treatment landscape for chronic lymphocytic leukemia (CLL), the most common leukemia in Western countries, has undergone a major shift with the advent of Bruton’s tyrosine kinase

VEXAS Syndrome: The Newly Discovered Disorder Every Hematologist Should Know

VEXAS Syndrome: The Newly Discovered Disorder Every Hematologist Should Know   Check back later for a possible video summary. Videos are created for most articles. Abstract This paper provides a comprehensive review of VEXAS syndrome; a newly recognized, adult-onset autoinflammatory condition with a genetic basis and complex multisystem involvement, carrying significant implications for hematologists, rheumatologists, and other specialists. First

Plasmapheresis in TTP Mimics: When Are We Getting It Wrong?

Plasmapheresis in TTP Mimics: When Are We Getting It Wrong?   Check back later for a possible video summary. Videos are created for most articles.     Introduction Plasmapheresis has revolutionized the treatment of thrombotic thrombocytopenic purpura (TTP), reducing mortality rates from nearly 100% to less than 10–20%. Despite this progress, diagnostic uncertainty remains a

Monoclonal Antibodies in Relapsed Multiple Myeloma: The Era of Bispecifics and Beyond

Monoclonal Antibodies in Relapsed Multiple Myeloma: The Era of Bispecifics and Beyond   Check back later for a possible video summary. Videos are created for most articles.   Abstract This paper provides an in-depth review of monoclonal antibody (mAb) therapies in the treatment of relapsed multiple myeloma (MM), with a particular focus on bispecific antibodies

Thrombocytopenia in the ICU: Essential Guide for Clinical Hematologists

Thrombocytopenia in the ICU: Essential Guide for Clinical Hematologists   Please like and subscribe if you enjoyed this video :-)     Introduction Thrombocytopenia is a frequent hematologic abnormality in critically ill patients, affecting up to 67.6% at ICU admission, with an additional 14–44% developing it during their stay.

Will AI Replace Pathologists? The Truth from Leading Hematology Labs in 2025