Tachyphylaxis in Antidepressants: The Science Behind Treatment Resistance

Tachyphylaxis in Antidepressants: The Science Behind Treatment Resistance   Introduction Tachyphylaxis is a challenging phenomenon that occurs when antidepressant medications gradually lose their therapeutic efficacy despite continued administration at the same dosage. The prevalence of antidepressant treatment tachyphylaxis is substantial, affecting approximately 25 percent of treated,

The Opioid Crisis in Family Practice: Safe Prescribing vs. Abandoning Patients

The Opioid Crisis in Family Practice: Safe Prescribing vs. Abandoning Patients Abstract The opioid crisis has placed family practice doctors in a challenging position. They must balance providing proper pain care for their patients while avoiding contributing to the widespread addiction and overdose problems facing

CBD and Seizures: New Clinical Evidence Challenges Common Beliefs

CBD and Seizures: New Clinical Evidence Challenges Common Beliefs   Introduction CBD and seizures research has skyrocketed in recent years, challenging traditional treatment paradigms for refractory epilepsy. Epilepsy affects approximately 50 million people globally, according to the World Health Organization (WHO). This neurological disorder, previously limited

Managing HIV in Primary Care: What Every Physician Needs to Know in 2025

Managing HIV in Primary Care: What Every Physician Needs to Know in 2025   Introduction HIV primary care has evolved dramatically, with more than 36 million people estimated to be living with HIV in 2019. The disease has claimed 39 million lives worldwide to date, yet its

ALS News: Breakthrough Drug Shows Promising Results in Clinical Trials

ALS News: Breakthrough Drug Shows Promising Results in Clinical Trials   Introduction Recent ALS news reveals a groundbreaking personalized drug therapy that has demonstrated remarkable efficacy in slowing ALS progression. In April 2024, a patient received the first-ever antisense oligonucleotide (ASO) treatment targeting CHCHD10 mutations in

Why Anesthesiologists Are Burning Out: A Veteran’s Perspective [2025 Crisis]

Why Anesthesiologists Are Burning Out: A Veteran’s Perspective [2025 Crisis]   Introduction Is being an anesthesiologist stressful? The answer lies in the alarming burnout rates that have reached crisis levels within the specialty. Burnout prevalence among anesthesiologists ranks among the highest of all medical

Sepsis-3 vs CMS Core Measures: Which Definition Should You Use?

Sepsis-3 vs CMS Core Measures: Which Definition Should You Use?   Introduction Sepsis core measures remain at the center of a critical clinical debate as sepsis continues to devastate healthcare systems nationwide. Each year, the incidence of severe sepsis increases by approximately 13% in

The Rise of Capsule Endoscopy in the Era of AI Analysis

The Rise of Capsule Endoscopy in the Era of AI Analysis  Abstract The integration of artificial intelligence (AI) with capsule endoscopy represents a paradigmatic shift in gastrointestinal diagnostics. It addresses the fundamental limitations of manual video review while enhancing diagnostic accuracy and efficiency. This analytical

Tachyphylaxis in Antidepressants: The Science Behind Treatment Resistance