Multimorbidity In Patients With Cognitive Impairment And Dementia Overview The study aimed to investigate the burden and clusters of multimorbidity in relation to mild cognitive impairment (MCI), dementia, and Alzheimer's disease (AD)-related plasma biomarkers among older adults. A population-based sample of 5432 participants aged 60 years and above was included, with a
Author: Nancy Ogbonna
Anticholinergic Medications And Cognitive Outcomes In Autistic Adults
Anticholinergic Medications And Cognitive Outcomes In Autistic Adults Overview This study investigates the impact of anticholinergic (AC) medications on cognitive outcomes in autistic adults, an area that has not been extensively researched. AC medications, known for their potential to cause cognitive impairment, are commonly used for various medical and psychiatric conditions. In
NSCLC First Line Therapy Chemotherapy Combinations
NSCLC First Line Therapy Chemotherapy Combinations Overview This retrospective study explores optimal first-line treatments for non-small cell lung cancer (NSCLC) patients with brain metastases (BMs) lacking driver gene alterations. The research compares the effectiveness of immunotherapy plus chemotherapy (ICI+Chemo) against bevacizumab plus chemotherapy (Beva+Chemo). The study, conducted between March 2017 and May
Colorectal Cancer: A Nomogram To Predict Metastases
Colorectal Cancer: A Nomogram To Predict Metastases Overview This study addresses the imperative task of identifying risk factors associated with distant metastasis in early-onset colorectal cancer (EOCRC), aiming to enhance understanding of its etiology and facilitate preventive treatments. The research, utilizing data from EOCRC patients in the SEER database (2010-2015), seeks to
Tongue Tumor Staging Using Artificial Intelligence
Tongue Tumor Staging Using Artificial Intelligence Overview This study addresses the critical issue of misdiagnosis in determining the stage of tongue tumor development, which can lead to varied treatment approaches and hinder patients from receiving appropriate care. The research aims to establish an automatic recognition system for different stages of tongue tumors,
Busulfan Exposure And Malignancy Risk
Busulfan Exposure And Malignancy Risk Overview The occurrence of secondary malignancies linked to busulfan exposure is deemed low but remains insufficiently characterized. Given the rising use of this alkylating agent in pre-gene therapy conditioning for nonmalignant hematologic disorders, a more precise understanding of busulfan's potential contribution to subsequent malignancy risk is essential.
Insulin Resistance Used To Assess Malignancies In Women
Insulin Resistance Used To Assess Malignancies In Women Overview In this prospective multicenter real-world cohort study involving 571 patients diagnosed with female reproductive system malignancies, the prognostic significance of insulin resistance (IR) and systemic inflammation was investigated. The cohort, with a mean age of 52 years, predominantly comprised individuals with cervical cancer
Thromboembolism Risk In Pregnant Oncology Patients
Thromboembolism Risk In Pregnant Oncology Patients Overview This systematic review and meta-analysis investigated the incidence of venous thromboembolism (VTE) in pregnant individuals with active malignancy compared to those without malignancy. The study, based on seven cohort studies encompassing 5,928 individuals with both active malignancy and pregnancy, yielded the following key findings:
Sinus Surgery Effectiveness Compared To Biological Therapies For Rhinosinusitis
Sinus Surgery Effectiveness Compared To Biological Therapies For Rhinosinusitis Overview This systematic review aims to compare the safety and efficacy of endoscopic sinus surgery (ESS) with various biologics in treating chronic rhinosinusitis with nasal polyps (CRSwNP) in adults by analyzing existing clinical trials. Five randomized controlled trials (RCTs) involving 1748 patients were
Fistula Presence As A Cancer Risk Factor In Crohn’s Disease
Fistula Presence As A Cancer Risk Factor In Crohn's Disease Overview In this retrospective cohort study, the researchers aimed to delve into the cancer risk among patients with Crohn's disease (CD) based on the presence or absence of perianal fistulas (PF). The study spanned from January 1, 2013, to December 31, 2014,
