Ocular Melanoma and Treatment with Metformin

Ocular Melanoma and Treatment with Metformin Metformin Activity  Metformin is one of the most common medications for patients with type 2 diabetes mellitus. It is an antihyperglycemic agent that activates the adenosine monophosphate-activated kinase (AMPK). Through this, a person’s cellular ATP levels are restored. The activation of AMPK by metformin suggests that

Gastric Neuroendocrine Neoplasms

Gastric Neuroendocrine Neoplasms Overview Gastric neuroendocrine neoplasms are rare lesions found in the stomach. They grow slowly and are often divided into four types based on their clinical characteristics. Type I lesions are found in the stomach and are linked with autoimmune chronic atrophic gastritis. Type II lesions are often caused by

Lung Cancer with Brain Metastasis After Late-Onset Bipolar Disorder: A Case Report

Lung Cancer with Brain Metastasis After Late-Onset Bipolar Disorder: A Case Report Background Bipolar disorder is a multifactorial illness with uncertain etiology and geriatric new-onset manic episodes are highly associated with secondary organic causes. The presented case demonstrates the importance of excluding secondary causes during the entire disease course.  Overview Bipolar disorder is a

Anlotinib with Camrelizumab in Lung Cancer Treatment

Anlotinib with Camrelizumab in Lung Cancer Treatment Background Checkpoint inhibitors (CPIs) and anti-angiogenic agents are emerging as potential novel treatment choices for advanced cancers including metastatic non-small-cell lung cancer (NSCLC). However, the combination of these two standard therapies has not been investigated in third-line or further-line treatment of patients with advanced NSCLC.

Sebaceous Carcinoma Treatment Outcomes: A Multicenter Study

Sebaceous Carcinoma Treatment Outcomes Sebaceous carcinoma (SC) is a rare tumor found in the sebaceous glands. The sebaceous gland is the gland that lubricates our skin. Although it can develop anywhere on the body, sebaceous carcinomas are often found on eyelids. It’s responsible for 0.7% of all cutaneous malignancies. From 2000

Diffuse-Type Tenosynovial Giant Cell Tumors: Treatments and Progression

Diffuse-Type Tenosynovial Giant Cell Tumors: Treatments and Progression Tenosynovial giant cell tumors (TGCT) - An Introduction Tenosynovial giant cell tumors (TGCT) are rare, locally invasive lesions of synovial origin that involve joints, tendon sheaths, and bursae.  TGCT may be intra- or extra-articular and is classified by growth pattern and clinical presentation as

Lung Spindle Cell Carcinoma Responsive to Pembrolizumab: A Rare Case Report

Lung Spindle Cell Carcinoma Responsive to Pembrolizumab: A Rare Case Report Overview  A male patient, 52 years of age, underwent pneumonectomy of the left lung. He was previously diagnosed with primary spindle cell carcinoma (pT4aN1M0, stage III B) with programmed death-ligand 1 expression (tumor proportion score ≥95%) and without epidermal growth factor

Breast Tomosynthesis Simulator for Virtual Clinical Trials

Breast Tomosynthesis Simulator for Virtual Clinical Trials Summary  The use of computer models and simulation in predicting the clinical performance of x-ray imaging devices in silico and generating synthetic patient images for training and testing of machine learning algorithms is widely accepted today.  In this study, the researchers presented a detailed description of

Isatuximab Treatment in Refractory T-Acute Lymphoblastic Leukemia