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Vancomycin – Single Level Analysis Advanced

Vancomycin - Single Level Analysis [Advanced version]
Patient:     Location:
Drug:   
Patient Age (yrs):   ?        Weight:  
Current dose being given:   mg    Current dosing interval: hrs
Current infusion time (hrs):  

Single level drawn - Trough
Trough level obtained:   mcg/ml
When was the trough drawn?:
Enter number of hours before next dose:   hrs
[Hint:   0.01 = <1 minute before next dose.   0.08 = ~5 minutes before next dose]
Desired peak:  mcg/ml   Desired trough:    mcg/ml
Select Vd Method: 
Volume of distribution:   L/kg   
Range: 0.5 - 0.95 (Usual: 0.7 L/kg)

Background
Ambrose-Winter’s Single Trough Method
Principles:
A population Vd is used to estimate the [Peak].
This calculated [Peak] and measured [Trough] are then used to calculate an elimination rate constant (kel).

[Peak]=measured [Trough] + Dose/Vd
kel = ln ([Peak]/[Trough])/Tau
Infusion equations are then used to calculate a new Tau and Dose.

Ambrose-Winter’s volume of distribution equation:
where Vd (L) = (0.17 × [age in years]) + (0.22 × [TBW in kg]) + 15
           (Note: TBW even if obese)

Reference

Ambrose PJ, Winter ME. In: Winter ME. Basic clinical pharmacokinetics, 4th ed. Philadelphia: Lippincott Williams & Wilkins; 2004:451-76.


Alternate expression of kel equation:
single level

Normally kel = (Ln C1 / C2) / (t2 - t1)
C1= actual or extrapolated Peak; or post peak level
C2= actual or extrapolated trough; or random level
Drawn at least 1.5 x estimated half-life after first level.
(t2 - t1) = Time difference between levels.

Equation 15.5 page 455:
cmax =  [cmin + dose (s) (f)] / Vd

Related pharmacokinetic calculators


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Allows the user to estimate the actual (extrapolated) trough based on the elimination rate constant and the number of hours the level was drawn before the next scheduled dose. A supratherapeutic level may be actually therapeutic if it was drawn just before the next dose. Trough drawn early? -Estimation Tool based on entered Kel
This new program can be used to determine when to administer the next dose of vancomycin after a supratherapeutic trough is obtained. An estimated elimination rate constant is generated from the creatinine clearance which is then used to determine the timing of the next dose based on the desired target trough concentration.
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Vancomycin – Single-level dosing


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Vancomycin – Empiric dosing


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