Vancomycin - Timing Of Next Dose Based On Est. Ke Value

Vancomycin -Timing of next dose based on estimated Ke value

This program can be used to determine when to administer the next dose of vancomycin after a supratherapeutic trough is obtained. An estimated elimination rate constant is generated from the creatinine clearance which is then used to determine the timing of the next dose based on the desired target trough concentration.

(Note: if the vancomcyin level is drawn early and you want to estimate the actual trough just before the next dose to determine if the current regimen is appropriate - use the following program.)

Estimated creatinine clearance: (mL/min)

Current trough: mcg/mL

Desired trough target (lower concentration): mcg/mL

Reference

Determination of Vancomycin Ke:

Matzke GR, McGroy RW, Halstenson CE et al. Pharmacokinetics of vancomycin in patients with various degrees of renal function. Antimicrob Agents Chemother. 1984; 25:433-437.
Matzke	(K_e) = 0.00083(CL_cr) + 0.0044

Related pharmacokinetic calculators

Trough Calculators

Allows the user to estimate the actual (extrapolated) trough based on the elimination rate constant and the number of hours the level was drawn before the next scheduled dose. A supratherapeutic level may be actually therapeutic if it was drawn just before the next dose. Trough drawn early? -Estimation Tool based on entered Kel

This new program can be used to determine when to administer the next dose of vancomycin after a supratherapeutic trough is obtained. An estimated elimination rate constant is generated from the creatinine clearance which is then used to determine the timing of the next dose based on the desired target trough concentration.
Vancomycin -Timing of next dose based on estimated Ke value

Use this program if the vancomcyin level is drawn early and you want to estimate the actual trough just before the next dose to determine if the current regimen is appropriate Vancomycin – Predicted Trough-Level drawn early

Dosing by levels

Dosing by levels (Full) Dosing by levels – pharmacokinetics (quick) Non-Steady State kinetics

Pharmacokinetics

Pharmacokinetics -Multiple Ke (Advanced version)Pharmacokinetic dosing -aminoglycosides/Vanco Original program

Vancomycin – Single-level dosing

Vancomycin SINGLE Level-(dosing by levels) Original calc

If you would like to enter the time since the last dose was given, use this version. This new version may be especially useful if the trough was drawn late and thenext dose was delayed. Example: current regimen vanco 1 gram q12h. Trough wasdrawn 12.5 hours after the last dose.Vancomycin single-level – dose infused early or late

The GlobalRPh vancomycin single-level calculator uses the Vd recommended in Bauer’s text: 0.7 L/kg. Use the advanced version if you wish to manipulate this value.Vancomycin single level – Advanced version