Menin Inhibitors in AML: Targeting KMT2A-Rearranged and NPM1-Mutated Disease Review Abstract Purpose Acute myeloid leukemia (AML) is a heterogeneous group of hematologic malignancies defined increasingly by recurrent molecular and cytogenetic abnormalities. KMT2A rearrangements and NPM1 mutations identify biologically distinct leukemias that frequently rely on menin-dependent
Tag: hematology oncology
Cytokine Release Syndrome 2.0: Managing Immune-Effector Toxicity as Cell Therapy Moves Earlier, Broader, and Beyond CAR T
Cytokine Release Syndrome 2.0: Managing Immune-Effector Toxicity as Cell Therapy Moves Earlier, Broader, and Beyond CAR T Review Abstract Purpose: This article reviews cytokine release syndrome (CRS) and related immune-effector toxicities in the expanding era of cellular therapy, with emphasis on practical recognition, risk stratification,
