From Skin to Gut: Unraveling the Immunopathogenesis of Eosinophilic Esophagitis Abstract Eosinophilic esophagitis (EoE) is a chronic, immune-mediated inflammatory disease of the esophagus [1] that has become a paradigmatic model for understanding the interconnected skin–gut axis in allergic disease. Once considered a rare disorder, EoE has rapidly emerged