ADAKVEO® (crizanlizumab-tmca)
Drug UPDATES: [Drug information (pdf)]
PACKAGE INSERT -Dosing: Click (+) next to Dosage and Administration section (drug info link)
Volume (mL) Adakveo=
[patient's body weight (kg) x 5 mg/kg]
-------------------------------------------
10 (Solution is 10 mg/mL)
Remove a volume of 0.9% Sodium Chloride Injection or 5% Dextrose Injection from the infusion bag/container that is equal to the required volume of ADAKVEO solution.
Must use a 0.2 micron inline filter.
Administer ADAKVEO 5 mg/kg by intravenous infusion over a period of 30 minutes at Week 0, Week 2, and every 4 weeks thereafter.
If a dose is missed, administer ADAKVEO as soon as possible.
If ADAKVEO is administered within 2 weeks after the missed dose, continue dosing according to the patient's original schedule.
If ADAKVEO is administered more than 2 weeks after the missed dose, continue dosing every 4 weeks thereafter.
ADAKVEO may be given with or without hydroxyurea.
ADAKVEO should be prepared and administered by a healthcare professional.
Preparation
- Use aseptic technique to prepare the solution for infusion.
- Calculate the dose (mg) and the total volume (mL) of ADAKVEO solution required, and the number of ADAKVEO vials needed based on the patient’s actual body weight.
- Prepare 5 mg of ADAKVEO per kg of actual body weight.
- Calculate the volume of ADAKVEO to be used according to the following equation:
Volume (mL)= [patient's body weight (kg) x 5 mg/kg] / 10
Dilution
Dilute ADAKVEO in 0.9% Sodium Chloride Injection, USP or 5% Dextrose Injection, USP to a total volume of 100 mL for intravenous infusion as follows:
- Obtain the number of vials required. One vial is needed for every 10 mL of ADAKVEO.
- Bring vials to room temperature for a maximum of 4 hours prior to the start of preparation (piercing the first vial).
- Visually inspect the vials.
- Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.
- ADAKVEO is clear to opalescent, colorless or may have a slightly brownish-yellow tint.
- Do not use if particles are present in the solution.
- Obtain a 100 mL 0.9% Sodium Chloride Injection or 5% Dextrose Injection infusion bag/container.
- Infusion bags/containers must be made of either polyvinyl chloride (PVC), polyethylene (PE), or polypropylene (PP).
- Remove a volume of 0.9% Sodium Chloride Injection or 5% Dextrose Injection from the infusion bag/container that is equal to the required volume of ADAKVEO solution.
- Withdraw the necessary amount of ADAKVEO solution and dilute by adding to the infusion bag/container containing 0.9% Sodium Chloride Injection or 5% Dextrose Injection.
- The volume of ADAKVEO added to the infusion bag/container should not exceed 96 mL.
- Gently invert the infusion bag to mix the diluted solution. DO NOT SHAKE.
- Single-dose vials. Discard unused portion.
Storage Conditions of the Diluted Solution
Administer ADAKVEO diluted solution as soon as possible. If not administered immediately, store the prepared solution either:
- At room temperature up to 25°C (77°F) for no more than 4.5 hours from the start of the preparation (piercing the first vial) to the completion of infusion.
- Under refrigeration at 2°C to 8°C (36°F to 46°F) for no more than 24 hours, from the start of the time of the preparation (piercing the first vial) to the completion of infusion. This includes the storage of the diluted solution and the time to warm up to room temperature. Protect the diluted solution from light during storage under refrigeration.
Administration
- Administer ADAKVEO diluted solution by intravenous infusion over a period of 30 minutes through an intravenous line, which must contain a sterile, nonpyrogenic 0.2 micron inline filter.
- No incompatibilities have been observed between ADAKVEO and infusion sets composed of PVC, polyethylene (PE-lined PVC), polyurethane (PU), and in-line filter membranes composed of polyethersulfone (PES, neutral and positively charged), positively charged polyamide (PA), and polysulphone (PSU).
- Do not mix or coadminister with other drugs through the same intravenous line.
- After administration of ADAKVEO, flush the line with at least 25 mL of 0.9% Sodium Chloride or 5% Dextrose Injection.
- Dispose of any unused product or waste material in accordance with local requirements.
Crizanlizumab-tmca is a P-selectin blocker humanized IgG2 kappa monoclonal antibody that binds to P-selectin. Crizanlizumab-tmca is produced using recombinant DNA technology in Chinese hamster ovary (CHO) cells. It is composed of 2 heavy chains, each containing 448 amino acids, and 2 light chains each containing 218 amino acids, with a theoretical molecular weight of approximately 146 kDa.
ADAKVEO (crizanlizumab-tmca) injection is supplied as a sterile, preservative-free, clear to opalescent, colorless to slightly brownish-yellow solution for dilution and subsequent administration by intravenous infusion. Each 10 mL vial contains 100 mg crizanlizumab-tmca, citric acid (5.4 mg), polysorbate 80 (2 mg), sodium citrate (50.5 mg), sucrose (753.3 mg) and water for injection with a pH of 6.
Crizanlizumab-tmca is a humanized IgG2 kappa monoclonal antibody that binds to P-selectin and blocks interactions with its ligands, including P-selectin glycoprotein ligand 1 (PSGL-1). Crizanlizumab-tmca can also dissociate preformed P-selectin/PSGL-1 complex.
Binding P-selectin on the surface of the activated endothelium and platelets blocks interactions between endothelial cells, platelets, red blood cells, and leukocytes.
ADAKVEO® is indicated to reduce the frequency of vasoocclusive crises (VOCs) in adults and pediatric patients aged 16 years and older with sickle cell disease.
None.
5.1 Infusion-Related Reactions
In the SUSTAIN clinical trial, infusion-related reactions (defined as occurring during/within 24 hours of infusion) were observed in 2 (3%) patients treated with ADAKVEO 5 mg/kg [see Adverse Reactions (6.1)].
In the postmarketing setting, cases of infusion-related reactions, including severe pain events, have been reported, which required hospitalizations. The majority of these infusion-related reactions occurred during the first and second infusions. The management of pain events has included acetaminophen, NSAIDs, opioids, antihistamines, intravenous fluids, and/or oxygen therapy. Some patients have also experienced subsequent complications, such as acute chest syndrome and fat embolism, particularly those treated with steroids.
Monitor for and advise patients of signs and symptoms of infusion-related reactions, which may include pain in various locations, headache, fever, chills, nausea, vomiting, diarrhea, fatigue, dizziness, pruritus, urticaria, sweating, and shortness of breath or wheezing.
Discontinue ADAKVEO infusion for severe infusion-related reactions and institute appropriate medical care [see Dosage and Administration (2.3)].
For management recommendations of a mild or moderate infusion-related reaction [see Dosage and Administration (2.3)].
Exercise caution with corticosteroids in patients with sickle cell disease unless clinically indicated (e.g., treatment of anaphylaxis).
5.2 Laboratory Test Interference
Interference with automated platelet counts (platelet clumping) has been observed following administration of ADAKVEO, in particular, when blood samples were collected in tubes containing ethylenediaminetetraacetic acid (EDTA). Mitigation strategies are recommendeD.
Most common adverse reactions (incidence > 10%) are nausea, arthralgia, back pain, abdominal pain, and pyrexia.
See PACKAGE INSERT for PATIENT COUNSELING INFORMATION and Medication Guide. Drug information (pdf)
Administer ADAKVEO 5 mg/kg by intravenous infusion over a period of 30 minutes at Week 0, Week 2, and every 4 weeks thereafter.
If a dose is missed, administer ADAKVEO as soon as possible.
If ADAKVEO is administered within 2 weeks after the missed dose, continue dosing according to the patient's original schedule.
If ADAKVEO is administered more than 2 weeks after the missed dose, continue dosing every 4 weeks thereafter.
ADAKVEO may be given with or without hydroxyurea.
ADAKVEO should be prepared and administered by a healthcare professional.
Preparation
- Use aseptic technique to prepare the solution for infusion.
- Calculate the dose (mg) and the total volume (mL) of ADAKVEO solution required, and the number of ADAKVEO vials needed based on the patient’s actual body weight.
- Prepare 5 mg of ADAKVEO per kg of actual body weight.
- Calculate the volume of ADAKVEO to be used according to the following equation:
Volume (mL)= [patient's body weight (kg) x 5 mg/kg] / 10
Dilution
Dilute ADAKVEO in 0.9% Sodium Chloride Injection, USP or 5% Dextrose Injection, USP to a total volume of 100 mL for intravenous infusion as follows:
- Obtain the number of vials required. One vial is needed for every 10 mL of ADAKVEO.
- Bring vials to room temperature for a maximum of 4 hours prior to the start of preparation (piercing the first vial).
- Visually inspect the vials.
- Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.
- ADAKVEO is clear to opalescent, colorless or may have a slightly brownish-yellow tint.
- Do not use if particles are present in the solution.
- Obtain a 100 mL 0.9% Sodium Chloride Injection or 5% Dextrose Injection infusion bag/container.
- Infusion bags/containers must be made of either polyvinyl chloride (PVC), polyethylene (PE), or polypropylene (PP).
- Remove a volume of 0.9% Sodium Chloride Injection or 5% Dextrose Injection from the infusion bag/container that is equal to the required volume of ADAKVEO solution.
- Withdraw the necessary amount of ADAKVEO solution and dilute by adding to the infusion bag/container containing 0.9% Sodium Chloride Injection or 5% Dextrose Injection.
- The volume of ADAKVEO added to the infusion bag/container should not exceed 96 mL.
- Gently invert the infusion bag to mix the diluted solution. DO NOT SHAKE.
- Single-dose vials. Discard unused portion.
Storage Conditions of the Diluted Solution
Administer ADAKVEO diluted solution as soon as possible. If not administered immediately, store the prepared solution either:
- At room temperature up to 25°C (77°F) for no more than 4.5 hours from the start of the preparation (piercing the first vial) to the completion of infusion.
- Under refrigeration at 2°C to 8°C (36°F to 46°F) for no more than 24 hours, from the start of the time of the preparation (piercing the first vial) to the completion of infusion. This includes the storage of the diluted solution and the time to warm up to room temperature. Protect the diluted solution from light during storage under refrigeration.
Administration
- Administer ADAKVEO diluted solution by intravenous infusion over a period of 30 minutes through an intravenous line, which must contain a sterile, nonpyrogenic 0.2 micron inline filter.
- No incompatibilities have been observed between ADAKVEO and infusion sets composed of PVC, polyethylene (PE-lined PVC), polyurethane (PU), and in-line filter membranes composed of polyethersulfone (PES, neutral and positively charged), positively charged polyamide (PA), and polysulphone (PSU).
- Do not mix or coadminister with other drugs through the same intravenous line.
- After administration of ADAKVEO, flush the line with at least 25 mL of 0.9% Sodium Chloride or 5% Dextrose Injection.
- Dispose of any unused product or waste material in accordance with local requirements.
No dose reductions are recommended. Management for infusion-related reactions for ADAKVEO is described in Table 1.
| Severity of Adverse Reaction | Recommendation |
| Mild to moderate infusion-related reactions |
|
| Severe infusion-related reactions |
|
aExercise caution with the use of corticosteroids in patients with sickle cell disease unless clinically indicated (e.g., treatment of anaphylaxis).
Injection: 100 mg/10 mL (10 mg/mL) as a clear to opalescent, colorless to slightly brownish-yellow solution in a single-dose vial.
How Supplied
ADAKVEO (crizanlizumab-tmca) injection is a sterile, clear to opalescent, colorless to slightly brownish-yellow solution for intravenous infusion supplied as:
Carton containing one 100 mg/10 mL (10 mg/mL) single-dose vial NDC 0078-0883-61
The single-dose vial has a rubber stopper and an aluminum cap with a plastic flip-off disk. Each 10 mL vial is made of Type 1 glass.
Storage and Handling
Store and transport refrigerated at 2°C to 8°C (36°F to 46°F) in the original carton to protect from light.
Do not shake. Do not freeze.
