AMPHOTERICIN B LIPID COMPLEX (ABELCET ®)
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Standard Dilutions [Amount of drug] [Infusion volume] [Infusion rate]
| ---Concentration 1 mg/ml---
[300 mg/ 240 ml] [2 hours]
[350 mg/280 ml] [2 hours]
[400 mg/ 320 ml] [2 hours]
Stability / Miscellaneous
| Indications: treatment of aspergillosis in patients who are refractory to or intolerant of conventional ampho-B therapy.
DOSAGE AND ADMINISTRATION
Renal toxicity of ABELCET®, as measured by serum creatinine levels, has been shown to be dose dependent. Decisions about dose adjustments should be made only after taking into account the overall clinical condition of the patient.
Preparation of Admixture for Infusion
DO NOT DILUTE WITH SALINE SOLUTIONS OR MIX WITH OTHER DRUGS OR ELECTROLYTES as the compatibility of ABELCET® with these materials has not been established. An existing intravenous line should be flushed with 5% Dextrose Injection before infusion of ABELCET®, or a separate infusion line should be used. DO NOT USE AN IN-LINE FILTER.
The admixed ABELCET® and 5% Dextrose Injection may be stored for up to 48 hours at 2° to 8°C (36° to 46°F) and an additional 6 hours at room temperature. Do not freeze. Any unused material should be discarded.