Helicobacter Pylori

Helicobacter pylori

Background:
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Other   (Gram Negative Bacilli)  
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>Aeromonas species:
     1] Aeromonas hydrophila
     2] Aeromonas veronii
     3] Aeromonas shubertii
>Bartonella species:
     1] Bartonella bacilliformis
     2] Bartonella henselae (organism responsible for cat scratch disease)
     3] Bartonella Quintana
     4] Other
>Campylobacter:
     1] Campylobacter fetus
     2] Campylobacter jejuni
>Capnocytophaga species:
     1] Capnocytophaga canimorsus
     2] Capnocytophaga ochracea
>Francisella tularensis
>Helicobacter pylori Led
>Legionella species: ( L. pneumophila)
>Plesiomonas shigelloides
>Vibrio species:
     1] Vibrio cholera
     2] Vibrio parahaemolyticus
     3] Vibrio damsela
     4] Other

Helicobacter pylori:  

  • Gram-negative, microaerophilic bacterium found in the stomach. 
  • Linked to cases of chronic gastritis and gastric ulcers. 
  • It is also linked to the development of duodenal ulcers and stomach cancer.
  • Over 80 percent of individuals infected with the bacterium are asymptomatic.

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Therapy:
Important considerations:  The choice of an agent should be based on local antimicrobial sensitivities, site of infection, cost, and comorbid conditions.   Generally, the most common agents/regimens are listed first.

  1. No allergies:  Standard PPI* (all equivalent)  PLUS clarithromycin 500 mg twice daily PLUS amoxicillin 1000 mg orally twice daily for 10 to14 days.
  2. PCN allergy:  Standard PPI* (all equivalent)  PLUS clarithromycin 500 mg twice daily PLUS metronidazole 500 mg twice daily for 10 to14 days.
  3. PCN allergy or failed one of the above regimens (quadruple therapy):   Standard PPI* (all equivalent)  PLUS  Bismuth subsalicylate 525 mg four times daily  PLUS  metronidazole 250 mg four times daily PLUS  tetracycline 500 mg four times daily for 10-14 days
Helicobacter Pylori