Archives: Drug classes

Second generation Cephalosporins Spectrum: Gram-positive: Less than first-generation. Gram-negative: Greater than first-generation: HEN (Haemophilus influenzae, Enterobacter aerogenes and some Neisseria + the PEcK [Activity against Proteus mirabilis, some Escherichia coli, and Klebsiella pneumoniae][Source: https://en.wikipedia.org/wiki/Cephalosporin] Antimicrobials - Infectious Disease Aminoglycosides Ansamycins/Rifamycins Antibiotics (Other) Anti- Fungals Anti-Herpetic Agents Anti-Influenza Agents Anti-Malarials Carbapenems Cephalosporins Fluoroquinolones Glycopeptides HIV (anti) Agents Lincosamides Lipopeptides Macrolides Monobactams Oxazolidones Penicillins Sulfonamide antibiotics Tetracyclines Tuberculosis (anti) agents Navigation (cephalosporins) First generation cephalosporins Second generation cephalosporins

Polypeptide Antibiotics Infectious Disease -ALL Agents (INDEX) Disclaimer - Please see package insert if applicable for additional information. The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgment. Neither GlobalRPh Inc. nor any other party involved in

Oxazolidones Background:     "Oxazolidinones are a class of compounds containing 2-oxazolidone in the structure. Oxazolidinones are mainly used as antimicrobials. The antibacterial effect of oxazolidinones is by working as protein synthesis inhibitors, targeting an early step involving the binding of N-formylmethionyl-tRNA to the ribosome. Some of the most important oxazolidinones are the

Monobactams Background:    "Monobactams are beta-lactam compounds wherein the beta-lactam ring is alone and not fused to another ring (in contrast to most other beta-lactams, which have at least two rings). They work only against aerobic Gram negative bacteria (e.g., Neisseria, Pseudomonas )." "The only commercially available monobactam antibiotic is aztreonam. They have

Disclaimer - Please see package insert if applicable for additional information. The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgment. Neither GlobalRPh Inc. nor any other party involved in the preparation of this program shall

Lincosamides Background: Lincosamides prevent bacteria replicating by interfering with the synthesis of proteins. They bind to the 23s portion of the 50S subunit of bacterial ribosomes and cause premature dissociation of the peptidyl-tRNA from the ribosome. Lincosamides do not interfere with protein synthesis in human cells (or those of other eukaryotes) because

Glycopeptides Infectious Disease -ALL Agents (INDEX)

Fourth generation Cephalosporins Spectrum: Gram-positive: "They are extended-spectrum agents with similar activity against gram-positive organisms as first-generation cephalosporins." Gram-negative: "Fourth-generation cephalosporins are zwitterions that can penetrate the outer membrane of gram-negative bacteria. They also have a greater resistance to beta-lactamases than the third-generation cephalosporins. Many can cross the blood–brain barrier and are effective

First generation Cephalosporins Background:  "Cephalosporins are bactericidal and have the same mode of action as other beta-lactam antibiotics (such as penicillins) but are less susceptible to penicillinases. Cephalosporins disrupt the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity. The final