Mepivacaine is indicated for production of local
anesthesia for dental procedures by infiltration or nerve block in adults and
DOSAGE AND ADMINISTRATION
As with all local anesthetics, the dose varies and
depends upon the area to be anesthetized, the vascularity of the tissues,
individual tolerance and the technique of anesthesia. The lowest dose needed to
provide effective anesthesia should be administered. For specific techniques
and procedures refer to standard dental manuals and textbooks.
For infiltration and block injections in the upper or
lower jaw, the average dose of 1 cartridge will usually suffice.
Each cartridge contains 1.7 mL (34 mg of 2% or 51 mg of 3%).
5.3 cartridges (180 mg of the 2% solution or 270 mg of
the 3% solution) are usually adequate to effect anesthesia of the entire oral
cavity. Whenever a larger dose seems to be necessary for an extensive
procedure, the maximum dose should be calculated according to the patient's
weight. A dose of up to 3 mg per pound of body weight may be administered. At
any single dental sitting the total dose for all injected sites should not
exceed 400 mg in adults.
The maximum pediatric dose should be carefully calculated.
Maximum dose for pediatric
population = Child’s Weight (lbs.) / 150Â X Maximum Recommended Dose 150
for Adults (400 mg)
The following table, approximating these calculations,
may also be used as a guide. This table is based upon a recommended maximum for
larger pediatric population of 5.3 cartridges (the maximum recommended adult
dose) during any single dental sitting, regardless of the pediatric patient's
weight or (for 2% mepivacaine) calculated maximum amount of drug:
|3% Mepivacaine Plain 3 mg/lb (270 mg max.)
||2% Mepivacaine 1:20,000 Levonordefrin 3 mg/lb (180 mg max.)
||Number of Cartridges
||Number of Cartridges
|* Adapted from Malamed, Stanley F: Handbook of medical
emergencies in the dental office, ed. 2, St. Louis, 1982. The C.V. Mosby Co.
When using Polocaine® for
infiltration or regional block anesthesia, injection should always be made
slowly and with frequent aspiration.
Any unused portion of a cartridge should be discarded.
Parenteral drug products should be inspected visually for
particulate matter and discoloration prior to administration, whenever solution
and container permit.
Disinfection Of Cartridges
As in the case of any cartridge, the diaphragm should be
disinfected before needle puncture. The diaphragm should be thoroughly swabbed
with either pure 91% isopropyl alcohol or 70% ethyl alcohol, USP, just prior to
use. Many commercially available alcohol solutions contain ingredients which
are injurious to container components, and therefore, should not be used.
Cartridges should not be immersed in any solution.
3% Polocaine® DENTAL; (Mepivacaine Hydrocholoride Injection
USP) (NDC 66312-441-16 ) is available in cardboard boxes containing 5 blisters
of 10 x 1.7 mL dental cartridges, 50 per carton.
2% Polocaine® DENTAL with Levonordefrin 1:20,000
(Mepivacaine Hydrochloride and Levonordefrin Injection; USP) (NDC 66312-461-16)
is available in cardboard boxes containing 5 blisters of 10 x 1.7 mL dental
cartridges, 50 per carton.
Both solutions should be stored at controlled room
temperature, below 25° C (77° F).
Protect from light. Do not permit to freeze.
BOXES: For protection from light, retain in box until time of use. Once opened,
the box should be reclosed by closing the top flap. The 2% Polocaine® DENTAL
with Levonordefrin 1:20,000 solution should not be used if its color is pinkish
or darker than slightly yellow or it contains a precipitate. Cartridge warmers
should not be used with Polocaine® products.
Manufactured for: DENTSPLY Pharmaceutical by Novocol Pharmaceutical of Canada, Inc., Cambridge, Ontario,
Canada N1R 6X3. Revised: Mar 2009