MICRONASE is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2
DOSAGE AND ADMINISTRATION
There is no fixed dosage regimen for the management of diabetes mellitus with MICRONASE Tablets. In
addition to the usual monitoring of urinary glucose, the patient's blood glucose must also be monitored
periodically to determine the minimum effective dose for the patient; to detect primary failure, ie, inadequate
lowering of blood glucose at the maximum recommended dose of medication; and to detect secondary failure,
ie, loss of adequate blood glucose lowering response after an initial period of effectiveness. Glycosylated
hemoglobin levels may also be of value in monitoring the patient's response to therapy.
Short-term administration of MICRONASE may be sufficient during periods of transient loss of control in patients
usually controlled well on diet.
Usual Starting Dose
The usual starting dose of MICRONASE Tablets is 2.5 to 5 mg daily, administered with breakfast or the first
main meal. Those patients who may be more sensitive to hypoglycemic drugs should be started at 1.25 mg
daily. (See PRECAUTIONS section for patients at increased risk.) Failure to follow an appropriate dosage
regimen may precipitate hypoglycemia. Patients who do not adhere to their prescribed dietary and drug
regimen are more prone to exhibit unsatisfactory response to therapy.
Transfer From Other Hypoglycemic Therapy Patients Receiving Other Oral Antidiabetic Therapy
Transfer of patients from other oral antidiabetic regimens to MICRONASE should be done conservatively and
the initial daily dose should be 2.5 to 5 mg. When transferring patients from oral hypoglycemic agents other
than chlorpropamide to MICRONASE, no transition period and no initial or priming dose are necessary. When
transferring patients from chlorpropamide, particular care should be exercised during the first two weeks
because the prolonged retention of chlorpropamide in the body and subsequent overlapping drug effects may
Patients Receiving Insulin
Some Type II diabetic patients being treated with insulin may respond satisfactorily to MICRONASE. If the insulin
dose is less than 20 units daily, substitution of MICRONASE Tablets 2.5 to 5 mg as a single daily dose may be
tried. If the insulin dose is between 20 and 40 units daily, the patient may be placed directly on MICRONASE
Tablets 5 mg daily as a single dose. If the insulin dose is more than
40 units daily, a transition period is required for conversion to MICRONASE. In these patients, insulin dosage is
decreased by 50% and MICRONASE Tablets 5 mg daily is started. Please refer to Titration to Maintenance Dose
for further explanation.
Patients Receiving Colesevelam
When colesevelam is coadministered with glyburide, maximum plasma concentration and total exposure to
glyburide is reduced. Therefore, MICRONASE should be administered at least 4 hours prior to colesevelam.
Titration To Maintenance Dose
The usual maintenance dose is in the range of 1.25 to 20 mg daily, which may be given as a single dose or in
divided doses (See Dosage Interval section). Dosage increases should be made in increments of no more than
2.5 mg at weekly intervals based upon the patient's blood glucose response.
No exact dosage relationship exists between MICRONASE and the other oral hypoglycemic agents. Although
patients may be transferred from the maximum dose of other sulfonylureas, the maximum starting dose of 5
mg of MICRONASE Tablets should be observed. A maintenance dose of 5 mg of MICRONASE Tablets provides
approximately the same degree of blood glucose control as 250 to 375 mg chlorpropamide, 250 to 375 mg
tolazamide, 500 to 750 mg acetohexamide, or 1000 to 1500 mg tolbutamide.
When transferring patients receiving more than 40 units of insulin daily, they may be started on a daily dose of
MICRONASE Tablets 5 mg concomitantly with a 50% reduction in insulin dose. Progressive withdrawal of insulin
and increase of MICRONASE in increments of 1.25 to 2.5 mg every 2 to 10 days is then carried out. During this
conversion period when both insulin and MICRONASE are being used, hypoglycemia may occur. During insulin
withdrawal, patients should test their urine for glucose and acetone at least three times daily and report results
to their physician. The appearance of persistent acetonuria with glycosuria indicates that the patient is a Type I
diabetic who requires insulin therapy.
Concomitant MICRONASE And Metformin Therapy
MICRONASE Tablets should be added gradually to the dosing regimen of patients who have not responded to
the maximum dose of metformin monotherapy after four weeks (see Usual Starting Dose and Titration to
Maintenance Dose). Refer to metformin package insert.
With concomitant glyburide and metformin therapy, the desired control of blood glucose may be obtained by
adjusting the dose of each drug. However, attempts should be made to identify the optimal dose of each drug
needed to achieve this goal. With concomitant glyburide and metformin therapy, the risk of hypoglycemia
associated with sulfonylurea therapy continues and may be increased. Appropriate precautions should be taken
Daily doses of more than 20 mg are not recommended.
Once-a-day therapy is usually satisfactory. Some patients, particularly those receiving more than 10 mg daily,
may have a more satisfactory response with twice-a-day dosage.
Specific Patient Populations
MICRONASE is not recommended for use in pregnancy or for use in pediatric patients.
In elderly patients, debilitated or malnourished patients, and patients with impaired renal or hepatic function,
the initial and maintenance dosing should be conservative to avoid hypoglycemic reactions. (See PRECAUTIONS.)
MICRONASE Tablets are supplied as follows:
MICRONASE Tablets 1.25 mg (White, Round, Scored, imprinted MICRONASE 1.25)
Bottles of 100 NDC 0009-0131-01
MICRONASE Tablets 2.5 mg (Dark Pink, Round, Scored, imprinted MICRONASE 2.5)
Bottles of 100 NDC 0009-0141-01
Bottles of 1000 NDC 0009-0141-03
Unit Dose Pkg of 100 NDC 0009-0141-02
MICRONASE Tablets 5 mg (Blue, Round, Scored imprinted MICRONASE 5)
Bottles of 30 NDC 0009-0171-11
Bottles of 60 NDC 0009-0171-12
Bottles of 100 NDC 0009-0171-05
Bottles of 500 NDC 0009-0171-06
Bottles of 1000 NDC 0009-0171-07
Unit Dose Pkg of 100 NDC 0009-0171-03
Store at controlled room temperature 20° to 25°C (68° to 77°F) [see USP]. Dispensed in well closed containers with safety closures. Keep container tightly closed.
Distributed by: Pfizer, Pharmacia and Upjohn, Division of pfizer Inc, NY 10017. Revised: July 2016.