FLUORESCITE® Injection 10% is indicated in diagnostic fluorescein angiography or angioscopy of
the retina and iris vasculature.
DOSAGE AND ADMINISTRATION
Adult Dose- The normal adult dose of FLUORESCITE® Injection 10% (100 mg/mL) is 500 mg via
For children, the dose should be calculated on the basis of 7.7 mg for each kg of actual body weight (or
35 mg for each 10 pounds of body weight) up to a maximum of 500 mg via intravenous administration.
Preparation For Administration
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to
administration. Do not mix or dilute with other solutions or drugs. Flush intravenous cannulas before
and after drugs are injected to avoid physical incompatibility reactions.
Inject the dose rapidly (1 mL per second is normally recommended) intravenously into the antecubital
vein, after taking precautions to avoid extravasation. A syringe, filled with FLUORESCITE® , may be
attached to transparent tubing and a 23 gauge butterfly needle for injection. Insert the needle and draw
the patient’s blood to the hub of the syringe so that a small air bubble separates the patient’s blood in the
tubing from the fluorescein. With the room lights on, slowly inject the blood back into the vein while
watching the skin over the needle tip. If the needle has extravasated, the patient’s blood will be seen to
bulge the skin and the injection should be stopped before any fluorescein is injected. When assured that
extravasation has not occurred, the room light may be turned off and the fluorescein injection
completed. Luminescence usually appears in the retina and choroidal vessels in 7 to 14 seconds and can
be observed by standard viewing equipment.
Reduction in dose from 5 mL to 2 mL of FLUORESCITE® Injection 10% may be appropriate in cases
when a highly sensitive imaging system e.g., scanning laser ophthalmoscope is used.
Dosage Forms And Strengths
Single use 5 mL vial containing 100 mg/mL fluorescein.
Storage And Handling
FLUORESCITE® (fluorescein injection, USP) 10% is supplied in a single use 5 mL glass vial with a
gray FluroTec coated chlorobutyl stopper and purple flip-off aluminum seal. The vial stopper is not
made with natural rubber latex. The vial contains a sterile, red-orange solution of fluorescein sodium.
Store at 2°- 25°C (36°- 77°F).
Do Not Freeze
Distributed By: Alcon Laboratories, Inc. Fort Worth, Texas 76134 USA. Revised: Feb 2016