Precise frequency data from controlled clinical studies
with CANTIL are not available.
Gastrointestinal System: vomiting, nausea,
constipation, loss of taste, bloated feeling, dry mouth
Central Nervous System: mental confusion,
dizziness, weakness, drowsiness, headache, nervousness
Ophthalmologic: increased ocular tension,
cycloplegia, blurred vision, dilation of the pupil
Cardiovascular: tachycardia, palpitations
Genitourinary: urinary retention, urinary
Miscellaneous : decreased sweating, drowsiness,
insomnia, impotence, suppression of lactation
Drug Abuse And Dependence
Tolerance, abuse, or dependence has not been reported
The following agents may increase certain actions or side
effects of anticholinergic drugs: amantadine, antiarrhythmic agents of class I
(e.g., quinidine), antihistamines, antipsychotic agents (e.g., phenothiazines),
benzodiazepines, MAO inhibitors, narcotic analgesics (e.g., meperidine),
nitrates and nitrites, sympathomimetic agents, tricyclic antidepressants, and
other drugs having anticholinergic activity.
Anticholinergics antagonize the effects of antiglaucoma
agents. Anticholinergic drugs in the presence of increased intraocular pressure
may be hazardous when taken concurrently with agents such as corticosteroids.
Anticholinergic agents may affect gastrointestinal
absorption of various drugs, such as slowly dissolving dosage forms of digoxin;
increased serum digoxin concentrations may result. Anticholinergic drugs may
antagonize the effects of drugs that alter gastrointestinal motility, such as metoclopramide.
Because antacids may interfere with the absorption of anticholinergic agents, simultaneous
use of these drugs should be avoided.
The inhibiting effects of anticholinergic drugs on
gastric hydrochloric acid secretion are antagonized by agents used to treat
achlorhydria and those used to test gastric secretion.