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Warfarin Dosing
Warfarin Dosing
Warfarin Dosing
Overview
Version 2.0 / Future versions of this program will likely contain proprietary algorithms that will support daily dosing. This current version provides general guidelines based on the information selected below. The responses are derived from statements found in the 6th ACCP guidelines. In many cases direct quotes are used from this valuable reference. Recent studies confirmed the importance of initiating warfarin therapy with lower doses (eg 5mg) as opposed to older protocols which advocated higher initial dosages (7.5 - 10mg).
Updated sections
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Warfarin Dosing Calculator
- Multiple dosing algorithms
Warfarin NOMOGRAMS utilized by the program
Therapeutic (INR Ranges) by indication
Warfarin (DRUG-DRUG) Interactions
Warfarin dosing summary- (based on 8th and 9th ACCP guidelines)
INRs - Treatment of ELEVATED levels
Warfarin - Maintenance dose adjustment
|
Calculator
Warfarin dose prediction calculator
Warfarin Inpatient dosing calculator with dose estimation
Bleeding risk: HAS-BLED bleeding risk score
Bleeding risk: HEMORR2HAGES Bleeding Risk Score
Warfarin: Low dose nomograms - Background data
What is the range of INR's I should target
?
Select an indication for warfarin therapy
Prophylaxis of venous thrombosis (high risk surgery)
Treatment of venous thrombosis (DVT)
Treatment of pulmonary embolism (PE)
Prevention of systemic embolism
Acute myocardial infarction (AMI)
Valvular Heart Disease
Atrial Fibrillation
Mechanical Prosthetic Valves (high risk)
Bileaflet mechanical valve in aortic position
Certain patients with thrombosis and antiphospholipid synd
Prevent recurrent MI
Initial dose above 5 mg
?
No
Yes
Does the patient have Protein C deficiency
:
No
Yes
What should I do if the patient's INR is outside the therapeutic range
?
Select INR range if elevated
INR above therapeutic range but less than 5.0
INR > 5.0 but less than 9. No significant bleeding
INR > 9.0 and no significant bleeding present
INR > 20 and serious bleeding
Life-threatening bleeding
Is the patient undergoing an invasive procedure
?
No
Yes