| Actions: Stimulates alpha-adrenergic receptors, increasing blood pressure and causing pronounced vasoconstriction in skin, mucous membranes, and mucosa. Produces mydriasis by contracting pupillary dilator muscle.
Nasal congestion: (ORAL)
Nasal decongestant (therapy should not exceed 3 continuous days):
Children >12 years and Adults: Instill 1-2 sprays or instill 1-2 drops every 4 hours of 0.25% to 0.5% solution as needed; 1% solution may be used in adult in cases of extreme nasal congestion; do not use nasal solutions more than 3 days
| Actions: Pseudoephedrine is a sympathomimetic amine. Its principal mechanism of action relies on its indirect action on the adrenergic receptor system. The vasoconstriction that pseudoephedrine produces is believed to be principally an α-adrenergic receptor response. While it may have weak or no direct agonist activity at α- and β-adrenergic receptors, the principal mechanism is to cause the release of endogenous norepinephrine (noradrenaline) from storage vesicles in presynaptic neurons.
Adults: 30 to 60 mg every 4-6 hours. Sustained release: 120 mg every 12 hours. Maximum: 240 mg/24 hours
National Institutes of Health, U.S. National Library of Medicine, DailyMed Database.
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