source scope and renal guidance
Before use: Penicillin G
Selected serious-infection rows agree with the retained UCSF summary; source-specific doses remain separate from other evidence.
What to reconcileChoose the indication, potassium/sodium formulation and dialysis setting; do not use these schedules for benzathine or procaine penicillin.
1 source identities and dates
Penicillin G potassium - aqueous IV, UCSF renal tablesUCSF Infectious Diseases Management Program | Source revision: Revision not established in selected retrieval
Adults; aqueous IV potassium salt. Selected serious-infection rows, not depot products.
Read this stored source Source-specific interpretation; independent clinician adjudication pending. Added: v6.3.
chelation and dialysis scope
Chelate removal is not a routine dialysis replacement dose
The source distinguishes unchanged dosing from slower radioactive-chelate elimination. Dialysis effluent can be radioactive.
What to reconcileConfirm the contaminant, exact chelator and radiation-protection plan; do not substitute edetate calcium disodium.
1 source identities and dates
GlobalRPh RX List - Ca-DTPAGlobalRPh-hosted RX List | Source revision: Source revision date not established in selected retrieval.
Ca-DTPA for internal plutonium, americium or curium contamination; not another calcium chelator.
Read this stored source Source-specific interpretation; independent clinician adjudication pending. Added: v5.7.
formulation scope
TURALIO: renal band, capsule strength and meal instructions must match
The renal reduction includes mild impairment and uses actual body weight in Cockcroft-Gault. The current retrieved regimen uses 125 mg capsules with a low-fat meal.
What to reconcileDo not mix the retrieved regimen with older fasting instructions or calculate combined hepatic/interaction reductions.
2 source identities and dates
GlobalRPh RX List - TURALIOGlobalRPh-hosted RX List | Source revision: Source revision date not established in selected retrieval.
Pexidartinib - TURALIO 125 mg capsules; selected renal passages, not a complete prescribing monograph.
Read this stored source TURALIO - official renal dose and food checkDailyMed / Daiichi Sankyo Inc. | Source revision: Prescribing information revised January 2025.
TURALIO - official renal dose and food check; selected renal passages, not a complete prescribing monograph.
Read this stored source Source-specific interpretation; independent clinician adjudication pending. Added: v5.0.
boundary units
Phenazopyridine: renal contraindication has no numerical cutoff in this source
The source contraindicates renal insufficiency without supplying a numeric CrCl definition.
What to reconcilePreserve the contraindication wording; seek an attributed threshold rather than inventing one.
1 source identities and dates
GlobalRPh RX List - PYRIDIUMGlobalRPh-hosted RX List | Source revision: Source revision date not established in selected retrieval.
Phenazopyridine - PYRIDIUM renal contraindication supplement; selected renal passages, not a complete prescribing monograph.
Read this stored source Source-specific interpretation; independent clinician adjudication pending. Added: v5.0.
retrieval gap
Missing RX dose subsection filled by exact DailyMed label
The selected RX retrieval supplied pharmacokinetics but not the renal dose ceiling. The exact DailyMed dose subsection is now included locally.
What to reconcileRead the official renal dose ceiling; the remaining full-label precautions still apply.
2 source identities and dates
GlobalRPh RX List - QsymiaGlobalRPh-hosted RX List | Source revision: Revision date not established in selected retrieval.
Fixed combination; selected pharmacokinetic source subsection only. Renal dose subsection was not available in the retrieved page body.
Read this stored source QSYMIA - phentermine/topiramate ER capsulesDailyMed / NLM; manufacturer prescribing information | Source revision: Revision date not established in selected retrieval.
QSYMIA fixed-combination extended-release capsules; renal ceiling, not a starting-dose or taper schedule.
Read this stored source Source difference identified; final patient-specific adjudication required. Added: vearlier.
monitoring scope
NUPLAZID: no adjustment still requires severe-renal caution
The label retains caution with severe impairment/ESRD despite its no-adjustment statement and dialysis PK observations.
What to reconcileReview the complete safety profile and interactions; do not translate no adjustment into no risk.
1 source identities and dates
GlobalRPh RX List - NUPLAZIDGlobalRPh-hosted RX List | Source revision: Source revision date not established in selected retrieval.
Pimavanserin - NUPLAZID; selected source sections, not a full prescribing monograph.
Read this stored source Source-specific interpretation; independent clinician adjudication pending. Added: v4.8.
institutional regimen difference
Three-hour and four-hour institutional protocols are not interchangeable
Sinai Health and UCSF differ in infusion duration, initial-to-maintenance timing, renal intervals and dialysis regimens. These are separate local pathways, not duplicate confirmations of one universal dose.
What to reconcileChoose an approved institution-specific pathway with infection, susceptibility, dialysis settings and IV access documented. Do not pair one source's dose with the other's interval or loading sequence.
2 source identities and dates
Sinai Health piperacillin/tazobactam - November 2025 policySinai Health Antimicrobial Stewardship | Source revision: Policy starting November 2025
Sinai Health adult inpatient policy effective November 2025; not an independently approved U.S. label regimen.
Read this stored source UCSF piperacillin/tazobactam - extended infusion and dialysisUCSF Infectious Diseases Management Program | Source revision: Source revision date not established in selected retrieval.
UCSF adult institutional policy; total combination grams. Exclusions and dialysis setting must match.
Read this stored source Source-specific interpretation; independent clinician adjudication pending. Added: v3.7.
label vs institutional guidance
Label and UCSF dialysis instructions differ
The RX short-infusion table separates nosocomial pneumonia and other indications and specifies an HD supplement. UCSF lists a different all-infection intermittent-HD schedule.
What to reconcileKeep the chosen regimen, infusion duration, indication and dialysis assumptions intact. Do not add the label supplement automatically to an institution's different regimen. Exactly 20 is also unassigned by UCSF's printed greater-than/less-than headings.
2 source identities and dates
GlobalRPh RX List - ZOSYN injectionGlobalRPh-hosted RX List | Source revision: Source revision date not established in selected retrieval.
Adult IV piperacillin/tazobactam, total combination grams, 30-minute infusion.
Read this stored source UCSF piperacillin/tazobactam - extended infusion and dialysisUCSF Infectious Diseases Management Program | Source revision: Source revision date not established in selected retrieval.
UCSF adult institutional policy; total combination grams. Exclusions and dialysis setting must match.
Read this stored source Source-specific interpretation; independent clinician adjudication pending. Added: v3.7.
source scope and renal guidance
The ZOSYN table is a 30-minute infusion protocol
The mirror separates nosocomial pneumonia from other adult indications and specifies total combination grams.
What to reconcileDo not attach an extended-infusion duration or another source interval to these short-infusion doses.
1 source identities and dates
GlobalRPh RX List - ZOSYNGlobalRPh-hosted RX List | Source revision: Revision not established in selected retrieval
ZOSYN adult, 30-minute IV infusion, indication-specific renal table. Not an extended-infusion or pediatric renal regimen.
Read this stored source Source-specific interpretation; independent clinician adjudication pending. Added: v6.1.
product strength limit
A labeled starting amount may not exist in this brand
The renal starting amount is lower than the available ZYPITAMAG strengths. The source directs use of another pitavastatin formulation.
What to reconcileVerify the dispensed formulation and strength; do not invent a splitting instruction or start at the renal maximum merely because that strength is available.
1 source identities and dates
GlobalRPh RX List - ZYPITAMAGGlobalRPh-hosted RX List | Source revision: Source revision date not established in selected retrieval.
Adult pitavastatin with ZYPITAMAG-specific strength limitation.
Read this stored source Source-specific interpretation; independent clinician adjudication pending. Added: v3.7.
population scope
PIVYA: alternative-treatment caution has no invented renal cutoff
The significant-impairment caution concerns carnitine risk, not a source-provided numerical renal table.
What to reconcileConsider the labeled alternative-treatment advice and interacting medicines; do not fabricate a CrCl contraindication boundary.
1 source identities and dates
GlobalRPh RX List - PIVYAGlobalRPh-hosted RX List | Source revision: Source revision date not established in selected retrieval.
Pivmecillinam - PIVYA tablets; selected renal passages, not a complete prescribing monograph.
Read this stored source Source-specific interpretation; independent clinician adjudication pending. Added: v5.0.
weight method and monitoring
Creatinine-clearance weight and dose weight are not the same
At the label's obesity threshold, Cockcroft-Gault uses ideal weight, while the mg/kg dose uses adjusted weight. Using one weight field for both would change one of the instructions.
What to reconcileDocument both weights and the initial versus concentration-adjusted interval. Use the trough procedure and daily renal reassessment; no dialysis or below-15 regimen is inferred.
1 source identities and dates
GlobalRPh RX List - ZEMDRIGlobalRPh-hosted RX List | Source revision: Source revision date not established in selected retrieval.
Adult IV plazomicin for complicated UTI; no extrapolated HD, CRRT or pediatric regimen.
Read this stored source Source-specific interpretation; independent clinician adjudication pending. Added: v3.7.
guideline difference
Polymyxin B: label-mirror reduction versus professional no-adjustment guidance
The RX mirror calls for renal reduction. UNMC recommends no loading or maintenance reduction for renal impairment or CRRT, citing international consensus. These recommendations are not silently harmonized.
What to reconcileRequest infectious-disease/pharmacy adjudication, document the chosen source and monitor toxicity. Do not construct a hybrid dose from opposing instructions.
2 source identities and dates
GlobalRPh RX List - POLYMYXIN BGlobalRPh-hosted RX List | Source revision: Source revision date not established in selected retrieval.
Polymyxin B - systemic injection; selected renal passages, not a complete prescribing monograph.
Read this stored source Polymyxin B - UNMC opposing renal guidanceUniversity of Nebraska Medical Center / antimicrobial stewardship | Source revision: Page revision not established; page cites 2019 international consensus guidance.
Polymyxin B - UNMC opposing renal guidance; selected renal passages, not a complete prescribing monograph.
Read this stored source Source-specific interpretation; independent clinician adjudication pending. Added: v5.0.
dialysis scope
POMALYST: indication, cycle days and HD timing remain linked
The dialysis dose differs between multiple myeloma and Kaposi sarcoma. The renal change does not remove the treatment-free portion of the 28-day cycle.
What to reconcileConfirm indication, days on treatment and post-HD administration; do not turn the modified dose into uninterrupted daily treatment.
2 source identities and dates
GlobalRPh RX List - POMALYSTGlobalRPh-hosted RX List | Source revision: Source revision date not established in selected retrieval.
Pomalidomide - POMALYST capsules; selected renal passages, not a complete prescribing monograph.
Read this stored source POMALYST - official hemodialysis and indication checkDailyMed / Celgene Corporation | Source revision: Prescribing information revised February 2025.
POMALYST - official hemodialysis and indication check; selected renal passages, not a complete prescribing monograph.
Read this stored source Source-specific interpretation; independent clinician adjudication pending. Added: v5.0.
evidence limit
PONVORY: no adjustment does not establish dialysis dosing
The renal exposure comparison does not answer the unstudied dialysis question.
What to reconcileRetain initiation and cardiac/infection safeguards; do not invent a dialysis supplement.
1 source identities and dates
GlobalRPh RX List - PONVORYGlobalRPh-hosted RX List | Source revision: Source revision date not established in selected retrieval.
Ponesimod - PONVORY tablets; selected renal passages, not a complete prescribing monograph.
Read this stored source Source-specific interpretation; independent clinician adjudication pending. Added: v5.0.
renal metric
The renal contraindication uses mL/kg/min, not indexed eGFR
The UROCIT-K renal cutoff is weight-normalized. Applying the same numeral to an automatically reported indexed eGFR would change its meaning.
What to reconcileCheck the original unit and renal potassium-excretion risk before considering any citrate regimen. The tool does not automatically convert this threshold or recommend a lower dose to bypass a contraindication.
1 source identities and dates
GlobalRPh RX List - Urocit-KGlobalRPh-hosted RX List | Source revision: Source revision date not established in selected retrieval.
Oral potassium citrate extended-release wax-matrix tablets.
Read this stored source Source-specific interpretation; independent clinician adjudication pending. Added: v3.6.