GlobalRPh Renal Dosing Masterv6.6
GlobalRPh source record

Fosfomycin - oral

Local RX List renal extractBase record retrieved 2026-09-05See the evidence for this drug4 sources available - open source summaries, references and comparisons
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Renal guidance at a glance

Cautions / source differences (1)

Confirm the product, indication and renal measure. The selected summary is not a complete prescribing monograph.

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Display order is not a clinical ranking. Date of retrieval is not the label revision date. Sources are never merged into one regimen. Other sources and conflicts remain below.

1 additional source qualifications - review before use
Labeled single-dose cystitis versus repeated institutional dosing

MONUROL labeling is limited to uncomplicated cystitis. UCSF separately supplies repeated oral doses for complicated cystitis and leaves CrCl exactly 50 unassigned between >50 and <50.

Before applying: Document the institutional/off-label rationale and exact renal band. Do not use these oral schedules for pyelonephritis or IV CONTEPO.

Also check: Labeled single-dose cystitis versus repeated institutional dosing

Rxlist source

GlobalRPh RX List - MONUROL

Product / population
Oral fosfomycin for labeled uncomplicated cystitis in women; not IV fosfomycin.
Renal measure
Renal PK observations include CrCl 7-54 mL/min; no renal interval table in the selected label.

RX mirror: this is not independent corroboration of its underlying label. Check dated-label and formulation limitations.

Renal dosing, restrictions and evidence limits

The labeled regimen is a single 3 g oral dose for uncomplicated cystitis; not pyelonephritis or perinephric abscess. Declining renal function prolonged elimination and reduced urinary recovery. The renal PK paragraph does not establish a repeated-dose schedule for complicated infection. Keep separately attributed institutional off-label schedules distinct from the label.

Source revision: Source revision date not established in selected retrieval. | Retrieved: 2026-09-07. Retrieval date is not the revision date.

Source: https://globalrph.com/rx-list/monurol-drug/

Scope: Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph. GlobalRPh v6.6.

Full source card / provenance

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Source-first renal review

Evidence sources and renal implications

Choose a source to jump directly to its locally stored result. Qualitative precautions and evidence gaps remain visible even when no numerical clearance schedule is supplied.

Read 1 source difference / applicability notes

Preserved GlobalRPh source

Preserved original GlobalRPh source

Preserved historical content; not revalidated as current prescribing guidance.

Renal method: Read the measure and population stated in the original source sections.
Retrieved: 2026-09-05

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GlobalRPh RX List

GlobalRPh RX List - MONUROL

Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.

Oral fosfomycin for labeled uncomplicated cystitis in women; not IV fosfomycin.

Renal method: Renal PK observations include CrCl 7-54 mL/min; no renal interval table in the selected label.
Retrieved: 2026-09-07

Read local renal resultOpen original reference
Professional guidance

UCSF - oral fosfomycin: cystitis regimens

Adults; oral fosfomycin for cystitis only.

Renal method: CrCl in mL/min where specified; no equation inferred.
Retrieved: 2026-09-05

Read local renal resultOpen original reference
Professional guidance

UCSF oral fosfomycin - cystitis schedules

Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.

Adult oral fosfomycin; complicated-cystitis repeated dosing is an institutional off-label use relative to MONUROL labeling.

Renal method: CrCl >50 versus <50 mL/min as printed; exactly 50 is not assigned.
Retrieved: 2026-09-07

Read local renal resultOpen original reference

Source presence is not independent validation. A label mirror is not a second independent source; review the original reference and exact formulation.

Product / population check

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These links compare product identities, not interchangeable doses. A selected summary is not a complete prescribing monograph.

Source-quality holds
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Jump to renal guidanceRead 1 difference / caution notesClinician guide

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Build a source-review outline for documentation

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Renal-context checklist: population, kidney trend and dialysis

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See source-specific renal methods and the clinical interpretation guide for the supporting context.

Read before choosing a regimen

Source differences and product cautions

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These are specific issues found during source review, not an automated judgment that one source is universally correct. A label mirror and its original label are not independent evidence.

indication scope difference

Labeled single-dose cystitis versus repeated institutional dosing

MONUROL labeling is limited to uncomplicated cystitis. UCSF separately supplies repeated oral doses for complicated cystitis and leaves CrCl exactly 50 unassigned between >50 and <50.

How to use this: Document the institutional/off-label rationale and exact renal band. Do not use these oral schedules for pyelonephritis or IV CONTEPO.

GlobalRPh RX List - MONUROLUCSF oral fosfomycin - cystitis schedulesFosfomycin disodium IV (CONTEPO)

Source-specific interpretation; independent clinician adjudication pending.

Go directly to the relevant source section

Renal dosing and precautions

Choose a source, then jump to its renal or dialysis section. These links locate stored text; they do not merge regimens or certify that sources agree.

New source summary - independent clinical review pending. Summaries of the identified label sections are included locally. Source import and numeric transcription checks are not independent two-reference validation. Do not treat this card as an approved institutional dosing protocol.

No dialysis or renal heading shown? Read the complete source summary. Absence of a heading is not evidence that dose adjustment is unnecessary.

Compare or copy source versions

All content below is stored locally. Read a whole source version; do not combine its dose with another source's interval, renal metric or dialysis assumptions.

Original content / product scopeGlobalRPh RX List - MONUROLUCSF - oral fosfomycin: cystitis regimensUCSF oral fosfomycin - cystitis schedules
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Historical source content is not a current prescription. Original GlobalRPh recommendations are preserved, not automatically certified as current. Product-label and professional additions below are separately attributed. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.

Important source distinctions

This qualitative statement remains a full source-specific protocol page. It is oral fosfomycin, not an IV protocol.

Locally stored source content

Original GlobalRPh protocol

Clinical facts and comments transcribed into a structured reading format. This is not a byte-for-byte HTML archive. Original source: https://globalrph.com/renal/fosfomycin/

Usual Dosing (Adults)

Uncomplicated urinary tract infection in females: mix 3 g powder in 3 to 4 ounces of water and drink as one dose.

GRPH-fosfomycin-01 · Source section: Usual Dosing (Adults)Renal section finder

Renal Dosing

Half-life increases with renal impairment; consider alternative therapy.

GRPH-fosfomycin-02 · Source section: Renal DosingRenal section finder
Locally imported selected renal sections

GlobalRPh RX List renal information

Rxlist

GlobalRPh RX List - MONUROL

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GlobalRPh-hosted RX List · Oral fosfomycin for labeled uncomplicated cystitis in women; not IV fosfomycin.

Renal method: Renal PK observations include CrCl 7-54 mL/min; no renal interval table in the selected label.
Source date: Source revision date not established in selected retrieval.
Retrieved: 2026-09-07

Label mirror, not independent corroboration. This is selected locally stored RX List content. Full monograph import and current official-label review are not implied.
Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.

Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph.

Renal dosing, restrictions and evidence limits

The labeled regimen is a single 3 g oral dose for uncomplicated cystitis; not pyelonephritis or perinephric abscess. Declining renal function prolonged elimination and reduced urinary recovery. The renal PK paragraph does not establish a repeated-dose schedule for complicated infection. Keep separately attributed institutional off-label schedules distinct from the label.

RDM41-rxlist-fosfomycin-a9090b9e08-C1 · Source locator: Indications, Dosage and Clinical Pharmacology / Renal Insufficiency

Source identity and provenance
Source family
product_label_mirror
Source
https://globalrph.com/rx-list/monurol-drug/
Retrieved
2026-09-07
Renal-function method
Renal PK observations include CrCl 7-54 mL/min; no renal interval table in the selected label.
Source date/version
Source revision date not established in selected retrieval.
Hash meaning
SHA-256 of local authored summary only; not original HTML, PDF or SPL bytes.
Local summary SHA-256
a80e8db1a21fa56e450c85f5bf18859d3769e2a2da4c29665fa99818c2f08972
Separate professional-source layer

University and professional protocols

Professional

UCSF - oral fosfomycin: cystitis regimens

Open original reference

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UCSF Infectious Diseases Management Program · Adults; oral fosfomycin for cystitis only.

Renal method: CrCl in mL/min where specified; no equation inferred.
Source date: Revision date not stated in the reviewed page.
Retrieved: 2026-09-05

Locally included source-specific summary. Regimen differences are not automatically resolved.

Dosing / renal protocol and limits

Uncomplicated cystitis: 3 g orally once, including renal impairment. Complicated cystitis is an institutional, off-label regimen: CrCl >50 mL/min, 3 g every 2 days for three doses; CrCl <50, 3 g every 3 days for three doses. Exactly 50 is not assigned by the webpage.

During intermittent HD, give the uncomplicated single dose after HD; for complicated cystitis, give 3 g every 3 days for three doses after HD. Continuous-HD data are not provided. These instructions concern oral fosfomycin, not intravenous products.

RDM30-029-fosfomycin-1 · Source locator: UCSF - oral fosfomycin: cystitis regimens; renal/dosing sections and stated qualifiers

Source identity and provenance
Source
https://idmp.ucsf.edu/content/fosfomycin-po
Retrieved
2026-09-05
Renal-function method
CrCl in mL/min where specified; no equation inferred.
Source date/version
Revision date not stated in the reviewed page.
Hash meaning
Locally authored summary text; not original SPL, HTML or PDF bytes
Local summary SHA-256
c2146cb1fea46178f7d199dc215b434d8a04f873af9c0f5bbc0a6975eb7e51fb
Professional

UCSF oral fosfomycin - cystitis schedules

Open original reference

Open / share this exact local source

UCSF Infectious Diseases Management Program · Adult oral fosfomycin; complicated-cystitis repeated dosing is an institutional off-label use relative to MONUROL labeling.

Renal method: CrCl >50 versus <50 mL/min as printed; exactly 50 is not assigned.
Source date: Source revision date not established in selected retrieval.
Retrieved: 2026-09-07

Dose or interval guidance. Use only the product, indication, renal metric and population described in this source.

Selected source text imported locally; independent clinical review pending. Not a complete prescribing monograph.

Renal dosing, restrictions and evidence limits

Uncomplicated cystitis: 3 g orally once in both printed renal bands. Complicated cystitis: 3 g every two days for three doses at CrCl >50, or every three days for three doses at CrCl <50. The page leaves exactly 50 unspecified; clarify that boundary.

Intermittent HD: uncomplicated cystitis 3 g once after HD; complicated cystitis 3 g every three days for three doses, after HD. Continuous-HD data are absent. These oral schedules are not treatment instructions for pyelonephritis or IV CONTEPO.

RDM41-professional-fosfomycin-c33511c96a-C1 · Source locator: Adult nondialysis and dialysis tables

Source identity and provenance
Source family
professional_guidance
Source
https://idmp.ucsf.edu/content/fosfomycin-po
Retrieved
2026-09-07
Renal-function method
CrCl >50 versus <50 mL/min as printed; exactly 50 is not assigned.
Source date/version
Source revision date not established in selected retrieval.
Hash meaning
SHA-256 of local authored summary only; not original HTML, PDF or SPL bytes.
Local summary SHA-256
40815ea13648a93b25cf841c4ed9f7123ee0e38254cd7bd1a7906aa28a0fb48d

Provenance and preservation

Additional summaries stored on this page: 0 official-label, 1 RX List, 2 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.

Original source
https://globalrph.com/renal/fosfomycin/
Source retrieval
2026-09-05. This is not the source publication or label revision date.
Original source type
globalrph individual
Local text SHA-256
bab3e9e57ab3d637490727b38ad19dbaf06bf9e6278e9874fdfa20d51807c9b5
Import versus clinical validation
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.

The original individual GlobalRPh pages commonly cite NIH/NLM DailyMed and instruct readers to review the applicable package insert for updates. That historical reference is preserved as context; it is not counted as an independently retrieved current label.

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