FRUZAQLA: source applicability and renal evidence limits
The warning uses <=Grade 1 recovery, while the dose-modification table supplies <1 g/24 hours or full resolution. The summary uses the quantitative table and retains the wording distinction, without blending baseline PK with toxicity management.
Before applying: Proteinuria >=2 g/24 hours: hold; use quantitative recovery and discontinuation rules below.
Use the renal measure and units named by this source. Confirm product, indication, age, stable versus changing kidney function, and exact dialysis modality. The selected summary is not a complete prescribing monograph. Renal method and dosing checklist
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Display order is not a clinical ranking. Date of retrieval is not the label revision date. Sources are never merged into one regimen. Other sources and conflicts remain below.
Official source
FRUZAQLA: selected primary-label renal guidance and limits
This source only - not a merged recommendation
What matters first
Product: Adult oral FRUZAQLA for labeled colorectal cancer; baseline renal PK and treatment-emergent proteinuria are separate decisions.
Renal action / finding
Baseline PK finding is not clearance for on-treatment proteinuria.
Evidence or dialysis limit
No ESRD/dialysis regimen established by the selected PK analysis.
Monitoring / application
Proteinuria >=2 g/24 hours: hold; use quantitative recovery and discontinuation rules below.
Selected-section summary, not a complete monograph. Independent clinician review remains pending. Read the exact renal measure, dates and full source below.
Product / population
Adult oral FRUZAQLA for labeled colorectal cancer; baseline renal PK and treatment-emergent proteinuria are separate decisions.
Renal measure
Cockcroft-Gault CrCl 15-89 mL/min (PK); proteinuria in g/24 hours (toxicity)
Source revision
Revision date not captured in selected review; retrieval date is not revision date.
Retrieved
2026-11-07 (not the revision date)
Renal toxicity or monitoring. On-treatment injury and monitoring instructions are not a baseline renal-dose schedule.
Before using this finding
No ESRD/dialysis regimen established by the selected PK analysis.
Selected renal section, not a complete prescribing monograph. A label and its mirror are not independent evidence.
Section 12.3; section 2.2/Table 2 and 5.6
PK was not meaningfully different at CrCl 15-89 mL/min; no ESRD/dialysis schedule is established by this observation. Check proteinuria before and during treatment. The dose-modification table instructs holding at >=2 g/24 hours until resolved or <1 g/24 hours, then resuming one dose level lower; permanently stop for nephrotic syndrome or failure to recover below 1 g/24 hours. The warning section describes recovery as <=Grade 1; the quantitative table controls this summary.
Source revision: Revision date not captured in selected review; retrieval date is not revision date. | Retrieved: 2026-11-07. Retrieval date is not the revision date.
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Source-specific interpretation
What the dialysis evidence actually supports
Removal information alone does not define a maintenance dose, supplemental dose or dialysis schedule. A reported regimen still requires its product, indication, renal measure and dialysis assumptions to match the patient.
FRUZAQLA: selected primary-label renal guidance and limits
Source retrieved 2026-11-07 - confirm current applicability
No dialysis regimen established in selected content
These manual classifications apply only to the identified selected sections, not every retained source or the entire prescribing information. They are not dosing clearance.
Source-first renal review
Evidence sources and renal implications
Choose a source to jump directly to its locally stored result. Qualitative precautions and evidence gaps remain visible even when no numerical clearance schedule is supplied.
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Renal-context checklist: population, kidney trend and dialysis
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These are specific issues found during source review, not an automated judgment that one source is universally correct. A label mirror and its original label are not independent evidence.
Source scope / renal recommendation differences
FRUZAQLA: source applicability and renal evidence limits
The warning uses <=Grade 1 recovery, while the dose-modification table supplies <1 g/24 hours or full resolution. The summary uses the quantitative table and retains the wording distinction, without blending baseline PK with toxicity management.
How to use this: Proteinuria >=2 g/24 hours: hold; use quantitative recovery and discontinuation rules below.
Choose a source, then jump to its renal or dialysis section. These links locate stored text; they do not merge regimens or certify that sources agree.
Independent clinical review is pending. These selected summaries are not an approved institutional dosing protocol. Confirm the exact product, the complete current source and local policy before use.
Official source
FRUZAQLA: selected primary-label renal guidance and limits
Adult oral FRUZAQLA for labeled colorectal cancer; baseline renal PK and treatment-emergent proteinuria are separate decisions.
No dialysis or renal heading shown? Read the complete source summary. Absence of a heading is not evidence that dose adjustment is unnecessary.
Compare or copy source versions
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Exact product and population matter. This added page contains locally stored, source-specific clinical summaries. Historical handbook information, when present, is identified separately and may conflict with U.S. labeling. Confirm indication, population, kidney-function method, monitoring and the full prescribing information before applying a regimen.
Important source distinctions
An RX mirror and its underlying label are not independent clinical confirmations.
DailyMed / product prescribing information · Adult oral FRUZAQLA for labeled colorectal cancer; baseline renal PK and treatment-emergent proteinuria are separate decisions.
Renal method: Cockcroft-Gault CrCl 15-89 mL/min (PK); proteinuria in g/24 hours (toxicity) Source date: Revision date not captured in selected review; retrieval date is not revision date. Retrieved: 2026-11-07
Renal toxicity or monitoring. On-treatment injury and monitoring instructions are not a baseline renal-dose schedule.
Before using this finding
No ESRD/dialysis regimen established by the selected PK analysis.
Dialysis evidence: No dialysis regimen established in selected content
Selected sections checked against the identified source; not a complete monograph or independent clinician approval.
Section 12.3; section 2.2/Table 2 and 5.6
PK was not meaningfully different at CrCl 15-89 mL/min; no ESRD/dialysis schedule is established by this observation. Check proteinuria before and during treatment. The dose-modification table instructs holding at >=2 g/24 hours until resolved or <1 g/24 hours, then resuming one dose level lower; permanently stop for nephrotic syndrome or failure to recover below 1 g/24 hours. The warning section describes recovery as <=Grade 1; the quantitative table controls this summary.
GlobalRPh RX List / label mirror · Adult oral FRUZAQLA for labeled colorectal cancer; baseline renal PK and treatment-emergent proteinuria are separate decisions.
Renal method: Cockcroft-Gault CrCl 15-89 mL/min (PK); proteinuria in g/24 hours (toxicity) Source date: Revision date not established in reviewed mirror passage. Retrieved: 2026-11-07
Label mirror, not independent corroboration. This is selected locally stored RX List content. Full monograph import and current official-label review are not implied.
Pharmacokinetic observation only. A drug-exposure observation is not itself a dose recommendation.
Before using this finding
No ESRD/dialysis regimen established by the selected PK analysis.
Dialysis evidence: No dialysis regimen established in selected content
Selected sections checked against the identified source; not a complete monograph or independent clinician approval.
Section 12.3; section 2.2/Table 2 and 5.6
The mirror PK passage includes CrCl 15-89 without a meaningful exposure difference. That baseline finding does not remove on-treatment proteinuria monitoring or dose-hold requirements.
Additional summaries stored on this page: 1 official-label, 1 RX List, 0 professional, 0 handbook. Empty additional-source groups are not shown. A missing layer is not a no-adjustment recommendation.
Source-section locators identify where retained content came from. A source-section identifier does not assert that every numeric statement has been independently corroborated. The local text hash is not a hash of original HTML, an FDA PDF or SPL XML.
This page is an additional exact-product entry, not a recovered GlobalRPh monograph. Its primary scope text and separately attributed clinical summaries are locally included.
