Actinomyces

Background:

Anaerobic Gram-positive nonspore-forming bacilli:
>Actinomyces led
>Bifidobacterium species
>Eubacterium
>Lactobacillus
>Propionibacterium

Actinomyces

  • Genus of the actinobacteria class of bacteria.
  • Gram-positive, rod-shaped, non-spore-forming, non-acid-fast, facultative anaerobe.
  • Actinomyces are facultatively anaerobic (except A. meyeri, a strict anaerobe).
  • Actinomyces species do not form endospores
  • Actinomyces colonies form fungus-like branched networks of hyphae.
  • Actinomyces are known for causing disease in humans and are normally present in the gums and are the most common cause of infection in dental procedures and oral abscesses.
  • Many Actinomyces species are opportunistic pathogens particularly in the oral cavity.

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Therapy:

Important considerations:  The choice of an agent should be based on local antimicrobial sensitivities, site of infection, cost, and comorbid conditions.   Generally, the most common agents/regimens are listed first.    Listed dosages may need to be adjusted for renal dysfunction.

  1. Amoxicillin 500mg orally three times daily or Ampicillin 2 grams IVPB every 4-6 hours
  2. Penicillin G 2-4 million units IV q4-6h or Penicillin VK 500mg orally every 6 hours
  3. Clindamycin  600mg IV every 6 or 8 hours or 300mg orally four times daily 
  4. Doxycycline 100mg orally twice daily
  5. Erythromycin 500mg orally four times daily 
  6. Ceftriaxone 1-2 grams IV q24h
  7. Others

Disclaimer

The authors make no claims of the accuracy of the information contained herein; and these suggested doses are not a substitute for clinical judgment. Neither GlobalRPh Inc. nor any other party involved in the preparation of this program shall be liable for any special, consequential, or exemplary damages resulting in whole or part from any user’s use of or reliance upon this material.PLEASE READ THE DISCLAIMER CAREFULLY BEFORE ACCESSING OR USING THIS SITE. BY ACCESSING OR USING THIS SITE, YOU AGREE TO BE BOUND BY THE TERMS AND CONDITIONS SET FORTH IN THE DISCLAIMER. Read the disclaimer