Oxytetracycline is indicated in infections caused by the following microorganisms:
Rickettsiae (Rocky Mountain spotted fever, typhus fever and the typhus group, Q fever, rickettsialpox and tick fevers),
Mycoplasma pneumoniae (PPLO, Eaton Agent),
Agents of psittacosis and ornithosis,
Agents of lymphogranuloma venereum and granuloma inguinale,
The spirochetal agent of relapsing fever (Borrelia recurrentis).
The following gram-negative microorganisms:
Haemophilus ducreyi (chancroid),
Pasteurella pestis, and Pasteurella tularensis,
Vibrio comma and Vibrio fetus,
Brucella species (in conjunction with streptomycin).
Because many strains of the following groups of microorganisms have been shown to be resistant to tetracyclines, culture and susceptibility testing are recommended.
Oxytetracycline is indicated for treatment of infections caused by the following gram-negative microorganisms, when bacteriologic testing indicates appropriate susceptibility to the drug:
Enterobacter aerogenes (formerly Aerobacter aerogenes ),
Mima species and Herellea species,
Haemophilus influenzae (respiratory infections),
Klebsiella species (respiratory and urinary infections).
Oxytetracycline is indicated for treatment of infections caused by the following gram-positive microorganisms when bacteriologic testing indicates appropriate susceptibility to the drug:
Up to 44 percent of strains of Streptococcus pyogenes and 74 percent of Streptococcus faecalis have been found to be resistant to tetracycline drugs. Therefore, tetracyclines should not be used for streptococcal disease unless the organism has been demonstrated to be sensitive.
For upper respiratory infections due to Group A beta-hemolytic streptococci, penicillin is the usual drug of choice, including prophylaxis of rheumatic fever.
Staphylococcus aureus , skin and soft tissue infections.
Oxytetracycline is not the drug of choice in the treatment of any type of staphylococcal infections.
When penicillin is contraindicated, tetracyclines are alternative drugs in the treatment of infections due to:
Treponema pallidum and Treponema pertenue (syphilis and yaws),
Fusobacterium fusiforme (Vincent's infection),
In acute intestinal amebiasis, the tetracyclines may be a useful adjunct to amebicides.
Tetracyclines are indicated in the treatment of trachoma, although the infectious agent is not always eliminated, as judged by immunofluorescence.
Inclusion conjunctivitis may be treated with oral tetracyclines or with a combination of oral and topical agents.
To reduce the development of drug-resistant bacteria and maintain effectiveness of Terramycin (oxytetracycline) IM and other antibacterial drugs, Terramycin (oxytetracycline) IM should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.