DOSAGE AND ADMINISTRATION
This preparation is specifically designed for use with "three-way" catheters or with other catheter systems permitting
continuous irrigation of the urinary bladder. The usual irrigation dose is one 1-mL ampul a day for up to 10 days.
Using strict aseptic techniques, the contents of one 1-mL ampul of NEOSPORIN G.U. Irrigant Sterile (neomycin sulfatepolymyxin
B sulfate solution for irrigation) should be added to a 1,000-mL container of isotonic saline solution. This container
should then be connected to the inflow lumen of the "three-way" catheter which has been inserted with full aseptic precautions;
use of a sterile lubricant is recommended during insertion of the catheter. The outflow lumen should be connected, via a sterile
disposable plastic tube, to a disposable plastic collection bag. Stringent procedures, such as taping the inflow and outflow
junction at the catheter, should be observed when necessary to insure the junctional integrity of the system.
For most patients, the inflow rate of the 1,000-mL saline solution of neomycin and polymyxin B should be adjusted to a slow
drip to deliver about 1,000 mL every 24 hours. If the patient's urine output exceeds 2 liters per day, it is recommended that the
inflow rate be adjusted to deliver 2,000 mL of the solution in a 24-hour period.
It is important that the rinse of the bladder be continuous; the inflow or rinse solution should not be interrupted for more than a
Preparation of the irrigation solution should be performed with strict aseptic techniques. The prepared solution should be stored
at 4°C, and should be used within 48 hours following preparation to reduce the risk of contamination with resistant
1-mL ampuls, boxes of 10 (NDC 61570-047-10) and 50 ampuls (NDC 61570-047-50); 20-mL multi-dose vial (NDC 61570-048-
Store at 2° to 8°C (36° to 46°F).
Distributed by: Pfizer Inc., Newyork., NY 10017. Revised: Oct 2016.