Gastrointestinal: anorexia, nausea, vomiting, diarrhea, epigastric
distress, abdominal pain, jaundice, cholestasis, parenchymal liver damage and
hepatic failure. (See WARNINGS.)
Central Nervous System: dizziness, weariness, drowsiness, giddiness,
headache, numbness, hyperirritability, convulsions, collapse, confusion, depression,
floating sensation, weakness and lack of coordination.
Special Senses: tinnitus, abnormal sensation in eyes, xanthopsia,
blurred vision, reduced vision, drying of mucous membranes (mouth, eyes, etc.),
Sicca syndrome. (See WARNINGS.)
Hematologic: transient leukopenia.
Genitourinary: hematuria, enuresis, malodor of the urine, crystalluria.
Hypersensitivity: pruritus, fever, facial flush, chills, conjunctival
injection, angioedema, anaphylaxis, skin rashes (including perianal), erythema
multiforme (including Stevens-Johnson syndrome), and lymphadenopathy.
Miscellaneous: appearance of live Ascaris in the mouth and nose.
Thiabendazole may compete with other drugs, such as theophylline, for sites
of metabolism in the liver, thus elevating the serum levels of such compounds
to potentially toxic levels. Therefore, when concomitant use of thiabendazole
and xanthine derivatives is anticipated, it may be necessary to monitor blood
levels and/or reduce the dosage of such compounds. Such concomitant use should
be administered under careful medical supervision.