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Methylene Blue Injection, USP is a sterile solution of methylene blue (methylene blue injection) in water for injection suitable for parenteral administration.
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Each mL of solution contains 10 mg of methylene blue (methylene blue injection) .
Drug induced methemoglobinemia.
0.1 to 0.2 mL per kilogram of body weight (0.045 to 0.09 mL per pound of body weight). Inject Methylene Blue (methylene blue injection) intravenously very slowly over a period of several minutes.
Methylene Blue (methylene blue injection) Injection, USP, 1% is supplied as follows:
NDC 11098-504-01
1 mL in 2 cc (partially filled) vials in packages of 10.
NDC 11098-504-10
10 mL vials in packages of 10.
NDC 11098-520-01 1 mL ampules in packages of 10.
NDC 11098-520-10 10 mL ampules in packages of 10.
The vials are packaged with a Flip Tear-Off Seal. The seal can either be flipped normally to reveal the rubber stopper or be totally removed so the rubber stopper can be taken out of the vial. The plastic button is attached to the metal seal, which when pulled, tears the seal at the score line allowing the metal portion to be removed.
Store at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature].
Flip Tear-Off Seal: Directions for Use:
Taylor Pharmaceuticals, An Akorn Company, Decatur, Illinois 62522. Rev. 03/06. FDA rev date: n/a
Large intravenous doses of Methylene Blue (methylene blue injection) produce nausea, abdominal and precordial pain, dizziness, headache, profuse sweating, mental confusion and the formation of methemoglobin.
Safety for use in pregnancy has not been established. Use of Methylene Blue (methylene blue injection) in women of childbearing potential requires that anticipated benefits be weighed against possible hazards.
No information provided.
Methylene Blue (methylene blue injection) should not be given by subcutaneous or intrathecal injection.
Methylene Blue (methylene blue injection) must be injected intravenously very slowly over a period of several minutes to prevent local high concentration of the compound from producing additional methemoglobin. Do not exceed recommended dosage.
No information provided.
Intraspinal injection is contraindicated.
Methylene blue (methylene blue injection) is Phenothiazin-5-ium, 3,7-bis (dimethylamino)-, chloride, trihydrate. It will produce two opposite actions on hemoglobin. Low concentrations will convert methemoglobin to hemoglobin. High concentrations convert the ferrous iron of reduced hemoglobin to ferric iron which results in the formation of methemoglobin.
No information provided. Please refer to the WARNINGS and PRECAUTIONS sections.
