Do not use unless solution is clear and seal is intact.
Manganese 0.1 mg/mL (Manganese Chloride Injection, USP)
should only be used in conjunction with a pharmacy directed admixture program
using aseptic technique in a laminar flow environment; it should be used
promptly and in a single operation without any repeated penetrations. Solution
contains no preservatives; discard unused portion immediately after admixture
procedure is completed.
Serum manganese levels can be measured periodically at
the discretion of the investigator. Because of the low serum concentration
normally present, samples will usually be analyzed by a reference laboratory.
Carcinogenesis, Mutagenesis, And Impairment Of Fertility
Long-term animal studies to evaluate the carcinogenic
potential of Manganese 0.1 mg/mL (Manganese Chloride Injection, USP) have not
been performed, nor have studies been done to assess mutagenesis or impairment
It is not known whether this drug is excreted in human
milk. Because many drugs are excreted in human milk, caution should be
exercised when Manganese 0.1 mg/mL (Manganese Chloride Injection, USP) additive
is administered to a nursing woman.
(See DOSAGE AND ADMINISTRATION section.) Safety
and effectiveness in pediatric patients have not been established.
Animal reproduction studies have not been conducted with
manganese chloride. It is also not known whether manganese chloride can cause
fetal harm when administered to a pregnant woman or can affect reproductive
capacity. Manganese chloride should be given to a pregnant woman only if
An evaluation of current literature revealed no clinical
experience identifying differences in response between elderly and younger
patients. In general, dose selection for an elderly patient should be cautious,
usually starting at the low end of the dosing range, reflecting the greater
frequency of decreased hepatic, renal, or cardiac function, and of concomitant
disease or other drug therapy.