Heparin Lock Flush Solution, USP is intended to maintain patency of an indwelling
venipuncture device designed for intermittent injection or infusion therapy
or blood sampling. Heparin lock flush solution may be used following initial
placement of the device in the vein, after each injection of a medication or
after withdrawal of blood for laboratory tests (see DOSAGE AND ADMINISTRATION,
Maintenance of Patency of IV Devices for directions for use).
Heparin lock flush solution is not to be used for anticoagulant therapy.
DOSAGE AND ADMINISTRATION
Parental drug products should be inspected visually for particulate matter
and discoloration prior to administration, whenever solution and container permit.
Slight discoloration does not alter potency.
Heparin Lock Flush Solution, USP is not recommended for use in the neonate
Maintenance of Patency of IV Devices
To prevent clot formation in a heparin lock set or central venous catheter
following its proper insertion, Heparin Lock Flush Solution, USP is injected
via the injection hub in a quantity sufficient to fill the entire device. This
solution should be replaced each time the device is used. Aspirate before administering
any solution via the device in order to confirm patency and location of needle
or catheter tip. If the drug to be administered is incompatible with heparin,
the entire device should be flushed with normal saline before and after the
medication is administered; following the second saline flush, the heparin lock
flush solution may be reinstilled into the device. The device manufacturer's
instructions should be consulted for specifics concerning its use. Usually this
dilute heparin solution will maintain anti-coagulation within the device for
up to 4 hours.
NOTE: Since repeated injections of small doses of heparin can alter
tests for activated partial thromboplastin time (APTT), a baseline value for
APTT should be obtained prior to insertion of a heparin lock set.
Withdrawal of Blood Samples
Heparin lock flush solution may also be used after each withdrawal of blood
for laboratory tests. When heparin would interfere with or alter the results
of blood tests, the heparin solution should be cleared from the device by aspirating
and discarding it before withdrawing the blood sample.
||HEPFLUSH®-10 (Heparin Lock Flush Solution, USP, Preservative Free),
10 USP Units/mL, in a 10 mL flip-top, single dose vial, in packages of
Unused portion of the vial should be discarded. Use only if solution
is clear and seal intact.
Store at 20°to 25°C (68°to 77°F) [see USP Controlled Room Temperature].
1. Tahata T, Shigehito M, Kusuhara K, Ueda Y, et al. Delayed-Onset
of Heparin Induced Throm-bocytopenia – A Case Report – J Jpn Assn Torca Surg.
2. Warkentin T, Kelton J. Delayed-Onset Heparin-Induced Thrombocytopenia
and Thrombosis. Annals of Internal Medicine. 2001;135:502-506.
3. Rice L, Attisha W, Drexler A, Francis J. Delayed-Onset Heparin
Induced Thrombocytopenia. Annals of Internal Medicine, 2002;136:210-215.
4. Dieck J., C. Rizo-Patron, et al. (1990). “A New Manifestation
and Treatment Alternative for Heparin-Induced Thrombosis.” Chest 98(1524-26).
5. Smythe M, Stephens J, Mattson. Delayed-Onset Heparin Induced
Thrombocytopenia. Annals of Emergency Medicine, 2005;45(4): 417-419.
6. Divgi A. (Reprint), Thumma S., Hari P., Friedman K., Delayed
Onset Heparin-Induced Thrombocytopenia (HIT) Presenting After Undocumented Drug
Exposure as Post-Angiography Pulmonary Embolism. Blood. 2003;102(11):127b.
APP Pharmaceuticals, LLC, Schaumburg, IL60173. For Product Inquiry:
1-800-551-7176. Revised: January 2008.