HEP-LOCK U/P (Preservative-Free Heparin Lock Flush Solution, USP) is intended
to maintain patency of an indwelling venipuncture device designed for intermittent
injection or infusion therapy or blood sampling. Heparin Lock Flush Solution
may be used following initial placement of the device in the vein, after each
injection of a medication or after withdrawal of blood for laboratory tests.
(See DOSAGE AND ADMINISTRATION, Maintenance of Patency of Intravenous
Devices for directions for use.)
HEP-LOCK U/P (preservative-free heparin lock flush solution) is not to be used for anticoagulant therapy.
DOSAGE AND ADMINISTRATION
Parenteral drug products should be inspected visually for particulate matter
and discoloration prior to administration, whenever solution and container permit.
Slight discoloration does not alter potency.
Preservative-Free Heparin Lock Flush Solution in the 100 unit/mL concentration
is not recommended for use in neonates and infants (see WARNINGS,
Use In Neonates and Infants).
Maintenance of Patency of Intravenous Devices
To prevent clot formation in a heparin lock set or central venous catheter
following its proper insertion, Preservative-Free Heparin Lock Flush Solution,
USP is injected via the injection hub in a quantity sufficient to fill the entire
device. This solution should be replaced each time the device is used. Aspirate
before administering any solution via the device in order to confirm patency
and location of needle or catheter tip. If the drug to be administered is incompatible
with heparin, the entire device should be flushed with normal saline before
and after the medication is administered; following the second saline flush,
Preservative-Free Heparin Lock Flush Solution, USP may be reinstilled into the
device. The device manufacturer's instructions should be consulted for specifics
concerning its use. Usually this dilute heparin solution will maintain anticoagulation
within the device for up to 4 hours.
NOTE: Since repeated injections of small doses of heparin can alter
tests for activated partial thromboplastin time (APTT), a baseline value for
APTT should be obtained prior to insertion of an intravenous device.
Withdrawal of Blood Samples
Preservative-Free Heparin Lock Flush Solution, USP may also be used after each
withdrawal of blood for laboratory tests. When heparin would interfere with
or alter the results of blood tests, the heparin solution should be cleared
from the device by aspirating and discarding it before withdrawing the blood
HEP-LOCK U/P (Preservative-Free Heparin Lock Flush Solution, USP)
10 USP units/mL
1 mL DOSETTE vials packaged in 25s (NDC 0641-0272-25)
100 USP units/mL
1 mL DOSETTE vials packaged in 25s (NDC 0641-0273-25)
Store at 20°-25°C (68°-77°F) [see USP Controlled Room Temperature].
7. Tahata T, Shigehito M, Kusuhara K, Ueda Y, et al. Delayed-Onset
of Heparin Induced Thrombocytopenia – A Case Report – J Jpn Assn Torca Surg.1992;40(3):110-111.
8. Warkentin T, Kelton J. Delayed-Onset Heparin-Induced Thrombocytopenia
and Thrombosis. Annals of Internal Medicine. 2001;135:502-506.
9. Rice L, Attisha W, Drexler A, Francis J. Delayed-Onset Heparin
Induced Thrombocytopenia. Annals of Internal Medicine, 2002;136:210-215.
10. Dieck J., C. Rizo-Patron, et al. (1990). “A New Manifestation
and Treatment Alternative for Heparin-Induced Thrombosis.” Chest 98(1524-26).
11. Smythe M, Stephens J, Mattson. Delayed-Onset Heparin Induced
Thrombocytopenia. Annals of Emergency Medicine, 2005;45(4):417-419.
12. Divgi A. (Reprint), Thumma S., Hari P., Friedman K., Delayed
Onset Heparin-Induced Thrombocytopenia (HIT) Presenting After Undocumented Drug
Exposure as Post-Angiography Pulmonary Embolism. Blood. 2003;102(11):127b.
ESI logo, Hep-Lock and Dosette are registered trademarks of Baxter International,
Inc., or its subsidiaries.
Manufactured by : Baxter Healthcare Corporation, Deerfield,
IL 60015 USA. For Product Inquiry 1 800 ANA DRUG (1-800-262-3784). FDA revision