For completeness, all major reactions to sulfonamides and to pyrimethamine
are included below, even though they may not have been reported with Fansidar
(see WARNINGS and PRECAUTIONS: Information
For The Patient).
Agranulocytosis, aplastic anemia, megaloblastic anemia, thrombocytopenia, leukopenia,
hemolytic anemia, purpura, hypoprothrombinemia, methemoglobinemia, and eosinophilia.
Skin and Miscellaneous Sites Allergic Reactions
Erythema multiforme, Stevens-Johnson syndrome, generalized skin eruptions,
toxic epidermal necrolysis, urticaria, serum sickness, pruritus, exfoliative
dermatitis, anaphylactoid reactions, periorbital edema, conjunctival and scleral
injection, photosensitization, arthralgia, allergic myocarditis, slight hair
loss, Lyell's syndrome,
Glossitis, stomatitis, nausea, emesis, abdominal pains, hepatitis, hepatocellular
necrosis, diarrhea, pancreatitis, feeling of fullness, and transient rise of
Central Nervous System Reactions
Headache, peripheral neuritis, mental depression, convulsions, ataxia, hallucinations,
tinnitus, vertigo, insomnia, apathy, fatigue, muscle weakness, nervousness,
Pulmonary infiltrates resembling eosinophilic or allergic alveolitis.
Renal failure, interstitial nephritis, BUN and serum creatinine elevation,
toxic nephrosis with oliguria and anuria, and crystalluria.
Drug fever, chills, periarteritis nodosa and LE phenomenon have occurred.
The sulfonamides bear certain chemical similarities to some goitrogens, diuretics
(acetazolamide and the thiazides), and oral hypoglycemic agents. Diuresis and
hypoglycemia have occurred rarely in patients receiving sulfonamides. Cross-sensitivity
may exist with these agents. Rats appear to be especially susceptible to the
goitrogenic effects of sulfonamides, and long-term administration has produced
thyroid malignancies in the species.