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Cinobac®
(cinoxacin)
Cinobac® (Cinoxacin, USP) is a synthetic antibacterial agent for oral administration. Cinoxacin, quinolone, is 1-ethyl-1,4-dihydro-4-oxo-[1,3] dioxolo [4,5-g] cinnoline-3-carboxylic acid and occurs as white or very light-yellow, needle-shaped crystals. Cinobac (cinoxacin) is available as 250-(0.95 mmol) and 500-mg (1.9 mmol) capsules. These capsules also contain D & C Yellow No. 10, F D & C Blue No. 1, F D & C Red No. 3, F D & C Yellow No. 6, gelatin, silicon dioxide, silicone fluid, sodium lauryl sulfate, starch, titanium dioxide, and other inactive ingredients.
The molecular formula is C12H10N2O5 and the molecular weight is 262.22.
Cinobac (cinoxacin) is indicated for the treatment of initial and recurrent urinary tract infections in adults caused by the following susceptible microorganisms: Escherichia coli, Proteus mirabilis, Proteus vulgaris, Klebsiella species (including K.pneumoniae), and Enterobacter species.
Cinobac (cinoxacin) is effective in preventing urinary tract infections for up to 5 months in women with a history of recurrent urinary tract infections.
In vitro susceptibility testing should be performed prior to administration of the drug and, when clinically indicated, during treatment.
The usual adult dosage for the treatment of urinary tract infections is 1 g daily, administered orally in 2 or 4 divided doses (500 mg b.i.d. or 250 mg q.i.d. respectively) for 7 to 14 days. Doses should be administered at least 2 hours before or 2 hours after antacids containing magnesium or aluminum, as well as sucralfate, metal cations such as iron, and multivitamin preparations with zinc or Videx (didanosine) chewable tablets or the pediatric powder for oral solution. Although susceptible organisms may be eradicated within a few days after therapy has begun, the full treatment course is recommended.
Impaired Renal Function: When renal function is impaired, a reduced dosage must be employed. After an initial dose of 500 mg, a maintenance dosage schedule should be used (see table).
| MAINTENANCE DOSAGE GUIDE FOR PATIENTS WITH RENAL IMPAIRMENT | ||
| Creatinine Clearance mL/min/1.73 m² | Renal Function | Dosage |
| >80 | Normal | 500 mg b.i. d. |
| 80-50 | Mild Impairment | 250 mg t.i. d. |
| 50-20 | Moderate Impairment | 250 mg b.i.d. |
