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Cholografin Meglumine
(lodipamide Meglumine Injection 52%) is a radiopaque contrast agent for rapid
intravenous cholangiography and cholecystography supplied as a sterile, aqueous
solution. Each mL provides 520 mg iodipamide meglumine; at manufacture, 3.2 mg
sodium citrate buffer and 0.4 mg edetate disodium sequestering agent are added
per mL. The pH has been adjusted between 6.5 and 7.7 with meglumine and
iodipamide. Each mL of solution also contains approximately 0.91 mg (0.039
mEq) sodium [18.2 mg/20 mL] and 257 mg organically bound iodine (5.2 g/20
mL). At the time of manufacture, the air in the container is replaced by
nitrogen.
The appearance of the solution
may vary from essentially colorless to light amber. Solutions which have become
substantially darker, however, should not be used.