DOSAGE AND ADMINISTRATION
Using a sterile syringe, inject 2.5 mL of Sterile Water
for Injection into the vial of Antivenin. With the needle still in the rubber
stopper, shake the vial to dissolve the contents completely.
Parenteral drug products should be inspected visually for
particulate matter prior to administration, whenever solution and container
permit (see DESCRIPTION).
The dose for adults and children is the entire contents
of a restored vial (2.5 mL) of Antivenin. It may be given intramuscularly,
preferably in the region of the anterolateral thigh so that a tourniquet may be
applied in the event of a systemic reaction. Symptoms usually subside in 1 to 3
hours. Although one dose of Antivenin usually is adequate, a second dose may be
necessary in some cases.
Antivenin also may be given intravenously in 10 to 50 mL
of saline solution over a 15 minute period. It is the preferred route in severe
cases, or when the patient is under 12, or in shock. One restored vial usually
No. 5424 — Antivenin (Latrodectus mactans), equine origin
is a white to gray crystalline powder, each vial containing not less than 6000
Antivenin units. Thimerosal (mercury derivative) 1:10,000 is added as preservative, NDC 0006-5424-02. A 1 mL vial of normal horse serum (1:10 dilution) for sensitivity
testing is also included. Thimerosal (mercury derivative) 1:10,000 is added as
Antivenin must be stored and shipped at 2-8°C (36-46°F).
When reconstituted as directed, the color of Antivenin ranges from light
(straw) to very dark (iced tea), but the color has no effect on potency. Do not
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Micks, D. W.: Insects and Other Arthropods of Medical
Importance in Texas, Tex. Rep. Biol. & Med. 18: 624-635, Winter 1960.
Prince, G. E.: Arachnidism in Children, J. Pediat. 49: 101-108,
Russell, F. E.: Injuries by Venomous Animals in the
United States, J. Amer. Med. Ass. 177: 903-907, Sept. 30, 1961.
Russell, F. E.: Muscle Relaxants in Black Widow Spider (Latrodectus
mactans) Poisoning, Amer. J. Med. Sci. 243: 159-162, Feb. 1962.
Russell, F. E.: Venom Poisoning, Rational Drug Therap. 5:
5-6, Aug. 1971.
Merck Sharp & Dohme Corp., a subsidiary of MERCK
& CO., INC Whitehouse Station, NJ 08889, USA. Revised: Mar 2015