In accord with the statements in the “Warning Box” the use of intramuscular bacitracin is limited to the
treatment of infants with pneumonia and empyema caused by staphylococci shown to be susceptible to
To reduce the development of drug-resistant bacteria and maintain the effectiveness of bacitracin and
other antibacterial drugs, bacitracin should be used only to treat or prevent infections that are proven or
strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are
available, they should be considered in selecting or modifying antibacterial therapy. In the absence of
such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of
DOSAGE AND ADMINISTRATION
TO BE ADMINISTERED INTRAMUSCULARLY ONLY
For infants under 2500 grams – 900 units/kg/24 hours in 2 or 3 divided doses. For infants
over 2500 grams – 1,000 units/kg/24 hours, in 2 or 3 divided doses. Intramuscular injections of the
solution should be given in the upper outer quadrant of the buttocks, alternating right and left and
avoiding multiple injections in the same region because of the transient pain following injection.
Preparation Of Solutions
Should be dissolved in sodium chloride injection containing 2 percent
procaine hydrochloride. The concentration of the antibiotic in the solution should not be less than 5,000
units per mL nor more than 10,000 units per mL.
Diluents containing parabens should not be used to reconstitute bacitracin; cloudy solutions and
precipitate formation have occurred.
Reconstitution of the 50,000 unit vial with 9.8 mL of diluent will result in a concentration of 5,000 units
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to
administration, whenever solution and container permit.
Bacitracin for Injection, USP is available in vials containing 50,000 units.
NDC 39822-0277-5. Boxes of ten vials use NDC 39822-0277-2.
Store the unrecons tituted product in a refrigerator 2° to 8°C (36° to 46°F).
Solutions are s table for one week when s tored in a refrigerator 2° to 8°C (36° to 46°F).
Manufactured for: X-Gen Pharmaceuticals, Inc. Big Flats, 14814. Revised: Revised: Jan 2013