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Atropine Injection, 2 mg
Autoinjector
A STERILE SOLUTION FOR INTRAMUSCULAR USE ONLY
FOR USE IN NERVE AGENT AND INSECTICIDE POISONING ONLY
CAUTION! PRIMARY PROTECTION AGAINST EXPOSURE TO CHEMICAL NERVE AGENTS AND INSECTICIDE POISONING IS THE WEARING OF PROTECTIVE GARMENTS INCLUDING MASKS DESIGNED SPECIFICALLY FOR THIS USE.
INDIVIDUALS SHOULD NOT RELY SOLELY UPON ANTIDOTES SUCH AS ATROPINE TO PROVIDE COMPLETE PROTECTION FROM CHEMICAL NERVE AGENTS AND INSECTICIDE POISONING.
SEEK IMMEDIATE MEDICAL ATTENTION AFTER INJECTION WITH ATROPINE .
Each single-dose prefilled autoinjector provides a 1.67 mg dose of atropine base (equivalent to 2 mg atropine sulfate) in a self-contained unit designed for self or caregiver administration.
Each 2 mg Atropine autoinjector delivers atropine in 0.7 mL of sterile pyrogen-free solution containing the inactive ingredients: citric acid and sodium citrate (buffer), glycerin 12.47 mg, and phenol 2.8 mg. The pH range is 4.1–4.5.
After the 2 mg Atropine autoinjector has been activated, the empty container should be disposed of properly (see DOSAGE AND ADMINISTRATION). It cannot be refilled, nor can the protruding needle be retracted.
Atropine, an anticholinergic agent (muscarinic antagonist), occurs as white crystals, usually needle-like, or as a white, crystalline powder. It is highly soluble in water with a molecular weight of 289.38. Atropine, a naturally occurring belladonna alkaloid, is a racemic mixture of equal parts of d-and l-hyoscyamine; its activity is due almost entirely to the levo isomer of the drug.
Chemically, atropine is designated as 1 H,5 H-Tropan-3 –ol (±) -tropate. Its empirical formula is C17H23NO3 and its structural formula is:
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Atropine is indicated for the treatment of poisoning by susceptible organophosphorus nerve agents having anticholinesterase activity as well as organophosphorus or carbamate insecticides in adults and pediatric patients weighing more than 41 kg (90 pounds).
First Dose
If the patient experiences two or more mild symptoms of nerve agent (nerve gas) or insecticide exposure listed in Table 1, administer one (1) Atropine injection intramuscularly into the mid-lateral outer thigh.
Additional Doses
If, at any time after the first dose, the patient develops any of the severe symptoms listed in Table 1, administer two (2) additional Atropine injections intramuscularly in rapid succession.
Wait 10 to 15 minutes for Atropine to take effect. If, after 10 to 15 minutes, the patient does not develop any of the severe symptoms listed in Table 1, no additional Atropine injections are recommended.
If possible, a person other than the patient should administer the second and third 2 mg Atropine autoinjectors.
If a patient is either unconscious or has any of the severe symptoms listed in Table 1, immediately administer three (3) Atropine injections intramuscularly into the patient’s mid-lateral outer thigh in rapid succession.
Table 1: Common Signs/Symptoms of Organophosphorus and/or Carbamate Poisoning
MILD symptoms include:
SEVERE symptoms include:
Each single-dose Atropine autoinjector contains atropine base 1.67 mg/0.7 mL (equivalent to atropine sulfate 2 mg/0.7 mL) in a sterile solution for intramuscular injection.
The 2 mg Atropine autoinjector provides atropine base 1.67 mg/0.7 mL (equivalent to atropine sulfate 2 mg/0.7 mL) in a sterile solution for intramuscular injection.
The 2 mg Atropine autoinjector is supplied as 480 self-contained single-dose autoinjectors per box (NDC 71053-592-01).
Store at 20°C to 25°C (68°F to 77°F); excursions permitted between 15°C to 30°C (59°F to 86°F) [see USP Controlled Room Temperature].
Do Not Freeze.
Manufactured by: RAFA LABORATORIES, LTD. JERUSALEM,ISRAEL. Revised: Jul 2019
The following serious adverse reactions are described elsewhere in the labeling:
The following adverse reactions associated with the use of atropine were identified in the literature. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
Mild to moderate pain may be experienced at the site of injection.
The major and most common side effects of atropine can be attributed to its antimuscarinic action. These include dryness of the mouth, blurred vision, dry eyes, photophobia, confusion, headache, dizziness, fatigue, tachycardia, palpitations, flushing, urinary hesitance or retention, constipation, abdominal pain, abdominal distention, nausea, vomiting, loss of libido, and impotency. Anhidrosis may produce heat intolerance and impairment of temperature regulation especially in a hot environment.
Hypersensitivity reactions will occasionally occur with atropine; these are usually seen as skin rashes, on occasion progressing to exfoliation. Anaphylactic reactions have occurred.
The following adverse reactions were reported in published literature for atropine in both adults and pediatric patients:
Sinus tachycardia, supraventricular tachycardia, junctional tachycardia, ventricular tachycardia, bradycardia, palpitations, ventricular arrhythmia, ventricular flutter, ventricular fibrillation, atrial arrhythmia, atrial fibrillation, atrial ectopic beats, ventricular premature contractions, bigeminal beats, trigeminal beats, nodal extrasystole, ventricular extrasystole, supraventricular extrasystole, asystole, cardiac syncope, prolongation of sinus node recovery time, cardiac dilation, left ventricular failure, myocardial infarction, intermittent nodal rhythm (no P wave), prolonged P wave, shortened PR segment, R on T phenomenon, shortened RT duration, widening and flattening of QRS complex, prolonged QT interval, flattening of T wave, repolarization abnormalities, altered ST-T waves, retrograde conduction, transient AV dissociation, increased blood pressure, decreased blood pressure, labile blood pressure, weak or impalpable peripheral pulses.
Mydriasis, pupils poorly reactive to light, decreased contrast sensitivity, decreased visual acuity, decreased accommodation, cycloplegia, strabismus, heterophoria, cyclophoria, acute angle closure glaucoma, conjunctivitis, keratoconjunctivitis sicca, blindness, tearing, dry conjunctiva, irritated eyes, crusting of eyelid, blepharitis.
Paralytic ileus, decreased bowel sounds, delayed gastric emptying, decreased food absorption, dysphagia.
Hyperpyrexia, lethargy, somnolence, chest pain, excessive thirst, weakness, syncope, insomnia, tongue chewing, dehydration, feeling hot.
Leukocytosis, hyponatremia, elevated BUN, elevated hemoglobin, elevated erythrocytes, low hemoglobin, hypoglycemia, hyperglycemia, hypokalemia, increase in photic stimulation on EEG, signs of drowsiness on EEG, runs of alpha waves on EEG, alpha waves (EEG) blocked upon opening eyes.
Failure to feed.
Ataxia, hallucinations (visual or aural), seizures (generally tonic-clonic), abnormal movements, coma, stupor, amnesia, diminished tendon reflexes, hyperreflexia, muscle twitching, opisthotnos, Babinski's reflex/Chaddock's reflex, hypertonia, dysmetria, muscle clonus, sensation of intoxication, difficulty concentrating, vertigo, dysarthria.
Agitation, restlessness, delirium, paranoia, anxiety, mental disorders, mania, withdrawn behavior, behavior changes.
Difficulty in micturation, urine urgency, distended urinary bladder, bed-wetting.
Tachypnea, slow respirations, shallow respirations, breathing difficulty, labored respirations, inspiratory stridor, laryngitis, laryngospasm, pulmonary edema, respiratory failure, subcostal recession.
Dry mucous membranes, dry warm skin, oral lesions, dermatitis, petechiae, rash, macular rash, papular rash, maculopapular rash, scarlatiniform rash, erythematous rash, sweating/moist skin, cold skin, cyanosed skin, salivation.
Administering additional 2 mg Atropine autoinjectors by mistake in the absence of actual nerve agent or insecticide poisoning may cause an overdose of atropine which could result in temporary incapacitation (inability to walk properly, see clearly or think clearly for several or more hours). Patients with cardiac disease may be at risk for serious adverse events, including death.
Amitai et al. (JAMA 1990) evaluated the safety of an atropine autoinjector in a case series of 240 children who received the atropine inappropriately (i.e., no nerve agent exposure) during the 1990 Gulf War Period. Overall, severity of atropinization followed a nonlinear correlation with dose. Estimated doses up to 0.045 mg/kg produced no signs of atropinization. Estimated doses between 0.045 mg/kg to 0.175 mg/kg and even greater than 0.175 mg/kg were associated with mild and severe effects respectively. Actual dosage received by children may have been considerably lower than estimated since incomplete injection in many cases was suspected. Regardless, adverse events reported were generally mild and self-limited. Few children required hospitalization. Adverse reactions reported were dilated pupils (43%), tachycardia (39%), dry membranes (35%), flushed skin (20%), temperature 37.8° C or 100° F (4%), and neurologic abnormalities (5%). There was also local pain and swelling. In patients with electrocardiograms, 22 of 91 (24%) children had severe tachycardia of 160-190 bpm. Neurologic abnormalities consisted of irritability, agitation, confusion, lethargy, and ataxia. Atropine 2mg is only approved for pediatric patients weighing more than 41kg at the recommended dosing.
When atropine and pralidoxime are used together, the signs of atropinization (flushing, mydriasis, tachycardia, dryness of the mouth and nose) may occur earlier than might be expected when atropine is used alone because pralidoxime may potentiate the effect of atropine. Excitement and manic behavior immediately following recovery of consciousness have been reported in several cases. However, similar behavior has occurred in cases of organophosphate poisoning that were not treated with pralidoxime.
Barbiturates are potentiated by the anticholinesterases; therefore, barbiturates should be used cautiously in the treatment of convulsions resulting from exposure to Atropine.
Included as part of the PRECAUTIONS section.
Cardiovascular adverse reactions reported in the literature for atropine include, but are not limited to, sinus tachycardia, palpitations, premature ventricular contractions, atrial flutter, atrial fibrillation, ventricular flutter, ventricular fibrillation, cardiac syncope, asystole, and myocardial infarction [see ADVERSE REACTIONS]. In patients with a recent myocardial infarction and/or severe coronary artery disease, there is a possibility that atropine-induced tachycardia may cause ischemia, extend or initiate myocardial infarcts, and stimulate ventricular ectopy and fibrillation. Atropine should be used with caution in patients with known cardiovascular disease or cardiac conduction problems.
Atropine may inhibit sweating which, in a warm environment or with excessive exercise, can lead to hyperthermia and heat injury. To the extent feasible, avoid excessive exercise and heat exposure [see ADVERSE REACTIONS].
Atropine may cause acute glaucoma and should be administered with caution in patients at risk for acute glaucoma or who have severe narrow angle glaucoma. Monitor for signs and symptoms of intraocular pressure, as appropriate.
Atropine may cause urinary retention and should be administered with caution to patients with clinically significant bladder outflow obstruction.
Atropine may cause complete pyloric obstruction in patients with partial pyloric stenosis. These patients should be monitored for gastrointestinal symptoms following administration of Atropine.
Atropine may cause thickening of bronchial secretions and formation of dangerous viscid plugs in individuals with chronic lung disease. Respiratory status should be monitored in individuals with chronic lung disease following administration of Atropine.
Atropine can cause hypersensitivity reactions, including anaphylactic reactions [see ADVERSE REACTIONS]. Medical supervision is necessary in patients who have had previous anaphylactic reactions to atropine and require treatment for organophosphorus or nerve agent poisoning.
Advise the patient to read the FDA-approved patient labeling (Instructions for Use).
Ensure that users understand the indications for and use of Atropine, including review of symptoms of poisoning and operation of the Atropine autoinjector [see DOSAGE AND ADMINISTRATION].
If feasible and appropriate, advise patients that Atropine is an initial emergency treatment, that they need additional care at a healthcare facility.
If feasible and appropriate, advise the patient to avoid a hot environment and excessive physical activity since atropine can inhibit sweating which can lead to overheating and heat injury.
No adequate studies regarding the carcinogenic potential of atropine have been conducted.
Studies to assess the mutagenic potential of atropine have not been conducted.
In studies in which male rats were orally administered atropine (62.5 to 125 mg/kg) for one week prior to mating and throughout a 5day mating period with untreated females, a dose-related decrease in fertility was observed. A no-effect dose for male reproductive toxicity was not established. The lowest dose tested was approximately 300 times (on a mg/m² basis) the dose of atropine in a single autoinjector application.
Fertility studies of atropine in females have not been conducted.
Atropine readily crosses the placental barrier and enters fetal circulation. There are no adequate data on the developmental risk associated with the use of atropine in pregnant women. Adequate animal reproduction studies have not been conducted with atropine.
In the U.S. general population, the estimated background risk of major birth defects and miscarriage in clinically recognized pregnancies is 2% to 4% and 15% to 20%, respectively. The background risk of major birth defects and miscarriage for the indicated population is unknown.
Atropine has been reported to be excreted in human milk. There are no data on the effects of atropine on the breastfed infant or the effects of the drug on milk production. The developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for Atropine and any potential adverse effects on the breastfed infant from Atropine or from the underlying maternal condition.
Safety and effectiveness of the 2 mg Atropine autoinjector in pediatric patients weighing less than or equal to 41 kg (90 pounds) have not been established.
Safety and effectiveness of atropine in patients weighing more than 41 kg (90 pounds) are supported by published literature. Adverse reactions seen in pediatric patients are similar to those that occur in adult patients. However, central nervous system effects are often seen earlier, and pediatric patients may be more susceptible to the pharmacologic effects of atropine [see ADVERSE REACTIONS].
Although the 2 mg Atropine autoinjector is not approved for pediatric patients less than 41 kg, overheating (atropine fever) caused by suppression of sweat gland activity may be more pronounced in infants and small children. Extreme hyperthermia in a newborn has been reported with as little as 0.065 mg orally.
Geriatric patients may be more susceptible to the pharmacologic effects of atropine [see ADVERSE REACTIONS].
Manifestations of atropine overdose are dose-related and include flushing, dry skin and mucous membranes, tachycardia, widely dilated pupils that are poorly responsive to light, blurred vision, and fever (which can sometimes be dangerously elevated). Locomotor difficulties, disorientation, hallucinations, delirium, confusion, agitation, coma, and central depression can occur and may last 48 hours or longer. In instances of severe atropine intoxication, respiratory depression, coma, circulatory collapse, and death may occur.
Supportive treatment should be administered as indicated. If respiration is depressed, artificial respiration with oxygen is necessary. Ice bags, alcohol sponges, or a hypothermia blanket may be required to reduce fever, especially in pediatric patients. Catheterization may be necessary if urinary retention occurs. Since atropine elimination takes place through the kidney, urinary output must be maintained and increased if possible; however, dialysis has not been shown to be helpful in overdose situations. Intravenous fluids may be indicated. Because of atropine-induced photophobia, the room should be darkened.
A benzodiazepine may be needed to control marked excitement and convulsions. However, large doses for sedation should be avoided because the central nervous system depressant effect may coincide with the depressant effect occurring late in severe atropine poisoning. Barbiturates are potentiated by the anticholinesterases; therefore, barbiturates should be used cautiously in the treatment of convulsions. Central nervous system stimulants are not recommended.
None.
Atropine competitively blocks the effects of acetylcholine, including excess acetylcholine due to organophosphorus poisoning, at muscarinic cholinergic receptors on smooth muscle, cardiac muscle, secretory gland cells, and in peripheral autonomic ganglia and the central nervous system.
Atropine reduces secretions in the mouth and respiratory passages, relieves the constriction and spasm of the respiratory passages, and may reduce the paralysis of respiration that results from toxic nerve agents which increase anticholinesterase activity in the central nervous system. Atropine-induced parasympathetic inhibition may be preceded by a transient phase of stimulation, especially on the heart where small doses first slow the rate before characteristic tachycardia develops because of paralysis of vagal control. Although mild vagal excitation occurs, the increased respiratory rate and occasionally increased depth of respiration produced by atropine are more probably the result of bronchiolar dilatation. Accordingly, atropine is an unreliable respiratory stimulant, and large or repeated doses may depress respiration.
Adequate doses of atropine can prevent or abolish various types of reflex vagal cardiac slowing or asystole. The drug also can prevent or abolish bradycardia or asystole produced by injection of choline esters, anticholinesterase agents or other parasympathomimetic drugs, and cardiac arrest produced by stimulation of the vagus. Atropine may also lessen the degree of partial heart block when vagal activity is an etiologic factor. In some individuals with complete heart block, the idioventricular rate may be accelerated by atropine; in others, the rate is stabilized. In some patients with conduction defects, atropine may cause paradoxical atrioventricular (A-V) block and nodal rhythm.
Systemic doses of atropine slightly raise systolic and lower diastolic pressures and can produce significant postural hypotension. Such doses also slightly increase cardiac output and decrease central venous pressure. Atropine can dilate cutaneous blood vessels, particularly in the “blush” area (atropine flush), and may cause overheating due to suppression of sweat gland activity [see WARNINGS AND PRECAUTIONS].
Atropine is well absorbed after intramuscular administration. Atropine is distributed throughout the various body tissues and fluids. Much of the drug is metabolized by enzymatic hydrolysis, particularly in the liver; from 13 to 50% is excreted unchanged in the urine. Atropine has been reported to be excreted in human milk [see Use In Specific Populations]. Atropine readily crosses the placental barrier and enters the fetal circulation.
The approximate Cmax of atropine following 1.67 mg atropine given intramuscularly to adults by the 2 mg AtroPen® delivery system was 9.6 ± 1.5 (mean ± SEM) ng/mL. The mean Tmax was 3 minutes. The T½ of intravenous atropine in pediatric subjects over 2 years is 2.5 ± 1.2 (mean ± SD) hours; in adults 16–58 years the T½ is 3.0 ± 0.9 (mean ± SD) hours; in geriatric patients 65–75 years it is 10.0 ± 7.3 (mean ± SD) hours. The protein binding of atropine is 14 to 22% in plasma. There are gender differences in the pharmacokinetics of atropine. The AUC(0-inf) and Cmax were 15% higher in females than males. The half-life of atropine is slightly shorter (approximately 20 minutes) in females than males.
Instructions for Use
ATROPINE injection, for intramuscular use 2 mg Atropine single-dose autoinjector
If possible, a healthcare provider or someone who has been trained to identify and treat the symptoms of exposure to nerve agents or insecticides should give (administer) the Atropine autoinjector. If a healthcare provider is not available during an emergency, a patient or a caregiver might need to give the Atropine injection.
Individuals should not rely only on Atropine for protection from nerve agent or insecticide poisoning. Patients and caregivers need to wear clothing to protect their skin and goggles and masks to protect their face and eyes when available to avoid exposure.
Leave the exposed (contaminated) area as quickly as possible.
Get medical help right away after exposure.
Step 1: Decide if the 2 mg Atropine autoinjector is right to use based on weight and age.
Step 2: Decide if symptoms are mild or severe using Table 1 below. The number of injections needed depends on if there are 2 or more mild symptoms or if there are any severe symptoms.
Note: You may not see all of these symptoms in yourself or others exposed to a nerve agent or certain insecticide poisoning.
Table 1. Symptoms of Nerve Agent or Insecticide Poisoning
Mild symptoms include:
Severe symptoms include:
Step 3: Decide the number of Atropine autoinjectors to use based on if the symptoms are mild or severe. See Table 1 and Figure 1.
Mild Symptoms (see Table 1)
First Dose: If you have or see someone with 2 or more mild symptoms listed in Table 1 and exposure is known or suspected, give 1 injection of Atropine into the outer thigh using the Atropine autoinjector. You can inject through clothing, but make sure pockets at the injection site are empty. Keep checking to see if symptoms continue or get worse. Get medical help right away.
Additional Doses: If at any time after the first dose (1 injection) the person who was exposed starts to have any of the severe symptoms listed in Table 1, you will need to give 2 more injections quickly one right after the other using a new Atropine autoinjector for each injection. Do not use the same autoinjector more than one time. If you have given yourself the first injection, someone else should give you the second and third injections, if possible.
You can inject additional doses through clothing, but make sure pockets at the injection site are empty.
No more injections are needed if the person who was exposed does not get sever symptoms 10 to 15 minutes after the first dose (1 injection).
Severe Symptoms (see Table 1)
If you have or see someone with any of the severe symptoms listed in Table 1 and exposure is known or suspected, or you see an exposed person passed out (unconscious), give 3 injections into the outer thigh quickly one right after the other, using 3 new autoinjectors.
You can inject through clothing, but make sure pockets at the injection site are empty. Get medical help right away.
Figure 1: Steps for deciding the number of Atropine
autoinjectors to use
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Step 4: Instructions for how to use the Atropine autoinjector
A.) Hold the plastic sleeve on both sides of the dotted lines (perforation) and tear apart at the edge to open. Remove the autoinjector from the plastic sleeve.
Be careful not to place fingers on the green tip.
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B.) Firmly hold the autoinjector with the green tip pointed down.
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C.) Pull off the yellow safety cap with your other hand.
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D.) Aim and firmly inject the green tip straight down (at a 90° angle) against the outer thigh. The autoinjector will give the medicine when you do this. You can inject through clothing, but make sure pockets at the injection site are empty.
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Note: People who may not have a lot of fat at the injection site should also be injected in the outer thigh. Before giving the injection, pinch a fold of skin firmly on the outer thigh to provide a thicker area for the injection.
E.) Hold the autoinjector firmly in place for at least 10 seconds to allow the injection to finish.
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F.) After 10 seconds, remove the autoinjector from the outer thigh and massage the injection site in a circle motion for several seconds.
Note: If you do not see the needle after removing it from the outer thigh, the injection is not completed.
Check to be sure the yellow safety cap has been removed. If the yellow safety cap has been removed, repeat Step 4 D) to Step 4 E) pressing more firmly against the outer thigh to activate the autoinjector.
If you still do not see the needle, use a new autoinjector and start over again at Step 4 A).
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G.) After the injection, avoid contact with blood or the needle by carefully bending the needle back against the autoinjector using a hard surface. Use the bent needle as a hook to pin the used autoinjector to the clothing of the person who has been exposed. This will allow medical personnel to see the number of Atropine autoinjectors given. You can also put the used autoinjector back into the plastic sleeve and leave it next to the person or write the dose and number of autoinjectors used on a triage tag, hand, forehead, chest or other part of the body. Move yourself and the exposed person away from the contaminated area right away. Get medical help right away.
Each autoinjector has only a single dose (1 injection) of medicine. If you need more than 1 injection, repeat the instructions in Step 4 using a new autoinjector for each injection.
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This Instructions for Use has been approved by the U.S. Food and Drug Administration.
