(cyclobenzaprine hydrochloride) Extended-release Capsules
Read this Patient Information before you start taking
AMRIX and each time you get a refill. There may be new information. This information
does not take the place of talking with your healthcare provider about your
medical condition or your treatment.
What is AMRIX?
AMRIX is a prescription medicine used along with rest and
physical therapy to help treat muscle spasm due to acute, painful
AMRIX should only be used for up to 2 or 3 weeks. It is
not known if AMRIX is effective when used for longer periods.
It is not known if AMRIX is safe and effective in
Who should not take AMRIX?
Do not take AMRIX if you:
- are allergic to cyclobenzaprine or any of the ingredients
in AMRIX. See the end of this Patient Information leaflet for a complete list
of ingredients in AMRIX.
Talk to your healthcare provider or get medical help
right away if you have symptoms of an allergic reaction such as:
- difficulty breathing
- swelling of your face or tongue
- are taking certain antidepressants, known as monoamine
oxidase (MAO) inhibitors or it has been 14 days or less since you stopped taking
a MAO inhibitor. Ask your healthcare provider or pharmacist for a list of these
medicines if you are not sure.
- have had a recent heart attack
- have heart rhythm problems (arrhythmias)
- have heart failure
- have an overactive thyroid (hyperthyroidism)
Talk to your healthcare provider before taking this
medicine if you have any of the conditions listed above.
What should I tell my healthcare provider before
Before you take AMRIX, tell your healthcare provider
- have a history of eye problems including glaucoma
- have heart problems or have had a heart attack
- have liver problems
- have trouble emptying your bladder (urinary retention)
- are pregnant or plan to become pregnant. It is not known
if AMRIX will harm your unborn baby.
- are breastfeeding or plan to breastfeed. It is not known
if AMRIX passes into your breast milk. You and your healthcare provider should
decide if you will take AMRIX or breastfeed.
AMRIX may affect the way other medicines work, and other
medicines may affect how AMRIX works.
Tell your healthcare provider about all the medicines
you take including prescription and non-prescription medicines, vitamins, and
Especially tell your healthcare provider if you take:
- a medicine to treat depression, mood, anxiety, psychotic
or thought disorders
- a pain medicine called tramadol or meperidine
- barbiturates or other medicines that depress your central
nervous system (CNS depressants)
- a medicine that prevents nerve impulses (anticholinergic
- a medicine to help quit smoking called bupropion
- a blood pressure medicine called verapamil
Ask your doctor or pharmacist if you are not sure if you
take any of the medicines listed above.
Know the medicines you take. Keep a list of your
medicines and show it to your healthcare provider or pharmacist when you get a new
How should I take AMRIX?
- Take AMRIX exactly as your healthcare provider tells you
to take it.
- Your healthcare provider will tell you how much AMRIX to
take and when to take it.
- Your healthcare provider may change your AMRIX dose if
- Take AMRIX around the same time every day.
- AMRIX should only be taken for short periods (up to two
or three weeks).
- If you take too much AMRIX, call your doctor or go to the
nearest hospital emergency room right away.
What should I avoid while taking AMRIX?
You should not drink alcohol until you know how AMRIX
affects you. Taking AMRIX with alcohol or other medicines that depress your
central nervous system can slow your thinking and physical response times.
Do not drive, operate machinery, or do other dangerous
activities until you know how AMRIX affects you.
What are the possible side effects of AMRIX?
AMRIX may cause serious side effects that may lead to
heart attack or stroke. Call your healthcare provider right away or go to the
nearest hospital emergency room if you have:
- irregular or abnormal heartbeats (arrhythmias)
- fast heartbeat (tachycardia)
Serotonin syndrome is a serious medical condition
that may happen when AMRIX is taken with certain other medicines. Call your
healthcare provider right away or go to the nearest hospital emergency room if
you become severely ill and have some or all of these symptoms:
- agitation, hallucinations, coma or other changes in
- coordination problems or muscle twitching (overactive
- fast heartbeat, high or low blood pressure
- sweating or fever
- nausea, vomiting, or diarrhea
- muscle stiffness or tightness
The most common side effects of AMRIX include:
- dry mouth
- upset stomach
Tell your healthcare provider if you get any side effect
that bothers you or that does not go away.
These are not all the possible side effects of AMRIX. For
more information, ask your healthcare provider or pharmacist.
Call your healthcare provider for medical advice about
You may report side effects to FDA at 1-800-FDA-1088.
How should I store AMRIX?
- Store AMRIX at room temperature, between 59° F to 86°F
(15°C to 30°C).
- Keep AMRIX in a tightly closed container, and keep AMRIX
out of light.
- Keep AMRIX and all medicines out of the reach of
General information about the safe and effective use
Medicines are sometimes prescribed for purposes other
than those listed in a Patient Information leaflet. Do not use AMRIX for a
condition for which it was not prescribed. Do not give AMRIX to other people,
even if they have the same symptoms you have. It may harm them.
This Patient Information leaflet summarizes the most
important information about AMRIX. If you would like more information, talk with
your healthcare provider. You can ask your healthcare provider or pharmacist
for information about AMRIX that is written for healthcare professionals.
For more information, go to www.AMRIX.com or call
What are the ingredients in AMRIX?
Active Ingredient: cyclobenzaprine hydrochloride
Inactive Ingredients: diethyl phthalate NF,
ethylcellulose NF (Ethocel Standard 10 Premium), gelatin, Opadry® Clear
YS-1-7006, sugar spheres NF (20-25 mesh), and titanium dioxide.
AMRIX 15 mg capsules also contain: D&C yellow
#10, FD&C green #3, and FD&C red #40.
AMRIX 30 mg capsules also contain: FD&C blue
#1, FD&C blue #2, FD&C red #40, and FD&C yellow #6.