Valacyclovir

Usual Dosing (Adults)

Herpes zoster (shingles): 1000mg po tid x 7 days.
Primary genital herpes: 1000mg po bid x 10 days.
Recurrent genital: 500mg po bid x 5 days.
Genital-chronic suppression: 500mg po qd.
Herpes labialis (cold sores) 2 gm q12h x 1 day.

Renal Dosing

[CRCL >50]: No changes

[30-49]: Zoster: 1 gram q12h. H. Labialis: 1 gram q12h x 2 doses. Initial episode Genital herpes: 1 gram q12h. Recurrent: 500mg q12h. Suppressive: 0.5 – 1 gm qd.

[10-29]: Zoster: 1 gram q24h. H. Labialis: 500mg q12h x 2 doses. Initial episode Genital herpes: 1 gram q24h. Recurrent: 500mg q24h. Suppressive: 500mg q24-48h.

[<10]: Zoster: 500mg q24h. H. Labialis: 500mg x 1. Initial episode Genital herpes: 500mg q24h. Recurrent: 500mg q24h. Suppressive: 500mg q24-48h.

Hemodialysis

Hemo:
500 mg PO q24h (on dialysis days give dose after dialysis)

Reference(s)

National Institutes of Health, U.S. National Library of Medicine, DailyMed Database.
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