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Usual Dosing (Adults)

7.5 mg/kg IV q8-12h.

Synercid should be administered by intravenous infusion in 5% Dextrose in Water solution over a 60-minute period. (See WARNINGS.) The recommended dosage for the treatment of infections is described in the table below. An infusion pump or device may be used to control the rate of infusion. If necessary, central venous access (e.g., PICC) can be used to administer Synercid to decrease the incidence of venous irritation.

Vancomycin-Resistant Enterococcus faecium: 7.5 mg/kg q8h
Complicated Skin and Skin Structure Infection: 7.5 mg/kg q12h

The minimum recommended treatment duration for Complicated Skin and Skin Structure Infections is seven days. For Vancomycin-Resistant Enterococcus faecium infection, the treatment duration should be determined based on the site and severity of the infection.

Renal Dosing

dialysis No adjustment necessary.


dialysis No adjustment necessary.


National Institutes of Health, U.S. National Library of Medicine, DailyMed Database.
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