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Spironolactone

Usual Dosing (Adults)
Edema (CHF, hepatic cirrhosis, or nephrotic syndrome): initial daily dosage of 100 mg given in single or divided doses ( range: 25 to 200 mg daily). When given as the sole agent for diuresis, should be continued for at least five days at the initial dosage level, after which it may be adjusted to the optimal therapeutic or maintenance level administered in either single or divided daily doses. 

Hypertension: initial dosage of 50 to 100 mg given in either single or divided doses. Aldactone may also be given with diuretics which act more proximally in the renal tubule or with other antihypertensive agents. Treatment with Aldactone should be continued for at least two weeks, since the maximum response may not occur before this time. 

Hypokalemia: Dosage ranging from 25 mg to 100 mg daily is useful in treating a diuretic-induced hypokalemia, when oral potassium supplements or other potassium-sparing regimens are considered inappropriate. 

Renal Dosing
dialysis Aldactone is contraindicated for patients with anuria, acute renal insufficiency, significant impairment of renal excretory function, or hyperkalemia.

Alternatively:
[>50 ml/min]: No changes
[10-50]: Give q12-24 hours.
[<10 ml/min]: Avoid use.

Hemodialysis
dialysis Avoid use.

Reference(s)
National Institutes of Health, U.S. National Library of Medicine, DailyMed Database.
Provides access to the latest drug monographs submitted to the Food and Drug Administration (FDA). Please review the latest applicable package insert for additional information and possible updates.  A local search option of this data can be found here.

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Spironolactone