Pyrazinamide

Usual Dosing (Adults)

15-30mg/kg po q24h (maximum 2g per day).
50 mg/kg twice weekly based on lean body weight (maximum 4g per day).

Renal Dosing

[>50 ml/min]: No change.

[<50 ]: Avoid use or reduce dose to 12-20 mg/kg/day.

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Manufacturer: It does not appear that patients with impaired renal function require a reduction in dose. It may be prudent to select doses at the low end of the dosing range, however.

Hemodialysis

Avoid use.

Reference(s)

National Institutes of Health, U.S. National Library of Medicine, DailyMed Database.
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