Primidone

Usual Dosing (Adults)

Seizure disorders: Initial: 125-250 mg/day orally at bedtime. Increase by 125 to 250 mg/day q3-7 days. Usual dose: 750-1500 mg/day in divided doses 3-4 times/day. Maximum dosage: 2 grams/day.

Renal Dosing

[CRCL 50-80 ml/min]: give q8h

[10-50]: Give q 8-12 hours.

[ <10 ]: Give q12-24 hours.

Hemodialysis

Dose as for CrCl<10 - on dialysis days supplement with 1/3 of usual dose AD

Reference(s)

National Institutes of Health, U.S. National Library of Medicine, DailyMed Database.
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