Pancuronium

Usual Dosing (Adults)

Neuromuscular blockade: Initial: 0.06-0.1 mg/kg or 0.05 mg/kg after initial dose of succinylcholine for intubation; maintenance dose: 0.01 mg/kg 60-100 minutes after initial dose and then 0.01 mg/kg every 25-60 minutes.

Neuromuscular blockade in the ICU: 0.05-0.1 mg/kg bolus followed by 0.8-1.7 mcg/kg/minute once initial recovery from bolus observed or 0.1-0.2 mg/kg every 1-3 hours

Renal Dosing

Elimination half-life is doubled, plasma clearance is reduced, and rate of recovery is sometimes much slower.
[CRCL 10-50 ml/min]: Administer 50% of normal dose.
[<10 ml/min]: Do not use.

Hemodialysis

Do not use.

Reference(s)

National Institutes of Health, U.S. National Library of Medicine, DailyMed Database.
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