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Usual Dosing (Adults)

Give loading dose of 50 mcg/kg slowly over 10 minutes, then start maintenance: 0.375 to 0.75 mcg/kg/min. 

PRIMACOR (milrinone lactate) should be administered with a loading dose followed by a continuous infusion (maintenance dose) according to the following guidelines:

50 mcg/kg: Administer slowly over 10 minutes

Note: PRIMACOR Flexible Containers (200 mcg/mL in 5% Dextrose Injection) are for intravenous infusion only and should not be used for a loading dose. Dosage recommendations using a 1mg/mL concentration of milrinone are included for informational purposes only. The loading dose should be administered using a milrinone 1mg/mL vial.

The table below shows the loading dose in milliliters (mL) of milrinone (1mg/mL) by patient body weight (kg).

Loading Dose (mL) Using 1 mg/mL Concentration

Patient Body Weight (kg)
kg 30 40 50 60 70 80 90 100 110 120
mL 1.5 2.0 2.5 3.0 3.5 4.0 4.5 5.0 5.5 6.0


Infusion Rate Total Daily Dose
(24 Hours)
Minimum 0.375 mcg/kg/min 0.59 mg/kg Administer as a
Standard 0.50 mcg/kg/min 0.77 mg/kg continuous
Maximum 0.75 mcg/kg/min 1.13 mg/kg intravenous infusion

The infusion rate should be adjusted according to hemodynamic and clinical response. Patients should be closely monitored. In controlled clinical studies, most patients showed an improvement in hemodynamic status as evidenced by increases in cardiac output and reductions in pulmonary capillary wedge pressure.

Renal Dosing

dialysis Recommended infusion rates (mcg/kg/min) per manufacturer:  
CRCL -  mL/min/1.73 m2 

[CRCL > 50]: No change
[50]: 0.43 mcg/kg/min
[40]: 0.38 mcg/kg/min
[30]: 0.33 mcg/kg/min
[20]: 0.28 mcg/kg/min
[10]: 0.23 mcg/kg/min
[5]: 0.2 mcg/kg/min


dialysis Hemodialysis:
Specific guidelines for hemodialysis are not mentioned by the manufacturer. See renal adjustments in the previous section.


National Institutes of Health, U.S. National Library of Medicine, DailyMed Database.
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